Characterization of dynamical changes in vital signs during allogeneic human umbilical cord-derived mesenchymal stem cells infusion

被引:0
|
作者
Wang, Yue [1 ]
Yu, Haiping [2 ]
Tang, Hongming [1 ,3 ]
Zhu, Rong [1 ]
Shi, Yiqi [1 ]
Xu, Changqin [1 ]
Li, Yan [1 ]
Wang, Hua [5 ]
Chen, Yuanyuan [3 ]
Shen, Peichen [4 ]
Xu, Jinfang [6 ]
Wang, Congrong [7 ]
Liu, Zhongmin [1 ,3 ]
机构
[1] Tongji Univ, Shanghai East Hosp, Clin Res Ctr Cell Therapy, Sch Med, Shanghai 200120, Peoples R China
[2] Tongji Univ, Shanghai East Hosp, Sch Med, Nursing Dept, Shanghai 200120, Peoples R China
[3] Tongji Univ, Shanghai East Hosp, Translat Med Ctr Stem Cell Therapy, Sch Med, Shanghai 200120, Peoples R China
[4] Tongji Univ, Shanghai East Hosp, Sch Med, Dept Med, Shanghai 200120, Peoples R China
[5] Shanghai Univ Tradit Chinese Med, Seventh Peoples Hosp, Catheterizat Room, Shanghai 200137, Peoples R China
[6] Second Mil Med Univ, Dept Hlth Stat, Shanghai 200433, Peoples R China
[7] Tongji Univ, Shanghai Peoples Hosp 4, Sch Med, Dept Endocrinol & Metab, Shanghai 200434, Peoples R China
来源
REGENERATIVE THERAPY | 2023年 / 24卷
关键词
Mesenchymal stem cells; Vital signs; Infusion; Allogeneic; Human umbilical cord; GROWTH-FACTOR;
D O I
10.1016/j.reth.2023.07.007
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs), a kind of adult stem cell, were studied for clinical applications in regenerative medicine. To date, the safety evaluations of intravenous infusion of allogeneic hUC-MSCs were focused on fever, infection, malignancy, and death. However, the characteristics of dynamical changes in vital signs during hUC-MSCs infusion are largely unknown. In this study, twenty participants with allogeneic hUC-MSCs transplanted (MSC group) and twenty sex- and age-matched individuals with cardiovascular disease who treated with the equal volume of 0.9% normal saline were recruited (NS group). Heart rate, respiratory rate, oxygen saturation, systolic and diastolic blood pressure, and temperature were monitored at intervals of 15 min during infusion. Adverse events were recorded during infusion and within seven days after infusion. No adverse events were observed during and after infusion in both groups. Compared with the baseline, the mean systolic blood pressure (SBP) levels were significantly decreased at 15 min, 30 min, 45 min and 60 min in the MSC group (all P < 0.05) during infusion. In addition, SBP changed significantly from baseline during hUC-MSCs infusion when compared with that of NS group (P < 0.05). Repeated measures analysis of variance confirmed difference over time on the SBP levels (P < 0.05). Our results showed that the process of allogeneic hUCMSCs intravenous infusion was safe and the vital signs were stable, whereas a slight decrease in SBP was observed.& COPY; 2023, The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/ 4.0/).
引用
收藏
页码:282 / 287
页数:6
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