Revisiting adipose thermogenesis for delaying aging and age-related diseases: Opportunities and challenges

被引：14

作者：

Tarantini, Stefano ^{[1
,2
,3
,4
]}

Subramanian, Madhan ^{[5
]}

Butcher, Joshua T.

Yabluchanskiy, Andriy ^{[1
,2
,3
,4
]}

Li, Xinna ^{[6
,7
]}

Miller, Richard A.

Balasubramanian, Priya ^{[1
,2
,4
,8
]}

机构：

[1] Univ Oklahoma, Dept Neurosurg, Neurodegenerat & Hlth Brain Aging Program, Hlth Sci Ctr,Vasc Cognit Impairment, Oklahoma City, OK USA

[2] Univ Oklahoma, Hlth Sci Ctr, Oklahoma Ctr Gerosci & Hlth Brain Aging, Oklahoma City, OK USA

[3] Univ Oklahoma, Hlth Sci Ctr, Coll Publ Hlth, Dept Hlth Promot Sci, Oklahoma City, OK USA

[4] Univ Oklahoma, Hlth Sci Ctr, Peggy & Charles Stephenson Canc Ctr, Oklahoma City, OK USA

[5] Oklahoma State Univ, Coll Vet Med, Dept Physiol Sci, Stillwater, OK USA

[6] Univ Michigan, Dept Pathol, Ann Arbor, MI USA

[7] Univ Michigan, Geriatr Ctr, Ann Arbor, MI USA

[8] Univ Oklahoma, Hlth Sci Ctr, Oklahoma Ctr Gerosci & Hlth Brain Aging, Dept Neurosurg, 940 Stanton L Young Blvd, BMSB842, Oklahoma City, OK 73104 USA

来源：

AGEING RESEARCH REVIEWS | 2023年 / 87卷

关键词：

Aging; Uncoupling protein 1; Thermogenesis; Futile metabolic cycling; Healthspan; Beta-3 adrenergic agonists; Adipose metabolism; DIET-INDUCED OBESITY; INSULIN SENSITIVITY; BROWN ADIPOCYTES; INDUCED LIPOKINE; COLD-EXPOSURE; ADULT HUMANS; VISCERAL FAT; TISSUE; BEIGE; ABLATION;

D O I：

10.1016/j.arr.2023.101912

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Adipose tissue undergoes significant changes in structure, composition, and function with age including altered adipokine secretion, decreased adipogenesis, altered immune cell profile and increased inflammation. Consid-ering the role of adipose tissue in whole-body energy homeostasis, age-related dysfunction in adipose metabolism could potentially contribute to an increased risk for metabolic diseases and accelerate the onset of other age -related diseases. Increasing cellular energy expenditure in adipose tissue, also referred to as thermogenesis, has emerged as a promising strategy to improve adipose metabolism and treat obesity-related metabolic disor-ders. However, translating this strategy to the aged population comes with several challenges such as decreased thermogenic response and the paucity of safe pharmacological agents to activate thermogenesis. This mini -review aims to discuss the current body of knowledge on aging and thermogenesis and highlight the unex-plored opportunities (cellular mechanisms and secreted factors) to target thermogenic mechanisms for delaying aging and age-related diseases. Finally, we also discuss the emerging role of thermogenic adipocytes in healthspan and lifespan extension.

引用

页数：9

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