Glucokinase maturity-onset diabetes of the young as a mimicker of stress hyperglycemia: a case report

被引：0

作者：

Nakasato, Yoshitaka ^{[1
]}

Terashita, Shintaro ^{[2
,7
]}

Kusabiraki, Shohei ^{[1
]}

Horie, Sadashi ^{[2
]}

Wada, Takuya ^{[3
]}

Nakabayashi, Motokazu ^{[4
]}

Nakamura, Megumi ^{[5
]}

Yorifuji, Tohru ^{[6
]}

机构：

[1] Itoigawa Gen Hosp, Dept Pediat, Niigata, Japan

[2] Toyama Univ Hosp, Dept Pediat, Toyama, Japan

[3] Toyama City Hosp, Dept Pediat, Toyama, Japan

[4] Hida Municipal Hosp, Dept Pediat, Gifu, Japan

[5] Nakamura Childrens Clin, Niigata, Japan

[6] Osaka City Gen Hosp, Childrens Med Ctr, Div Pediat Endocrinol & Metab, Osaka, Japan

[7] Univ Toyama, Fac Med, Dept Pediat, 2630 Sugitani, Toyama, Toyama 9300194, Japan

来源：

CLINICAL PEDIATRIC ENDOCRINOLOGY | 2023年 / 32卷 / 01期

关键词：

glucokinase; stress hyperglycemia; maturity-onset diabetes of the young; PREVALENCE; CHILDREN; MODY;

D O I：

10.1297/cpe.32.2022-0024

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Febrile seizures are frequently accompanied by stress-induced hyperglycemia. Herein, we report the case of a 1.5-yr-old girl with hyperglycemia during febrile seizures who was subsequently diagnosed with glucokinase (GCK) maturity-onset diabetes of the young (MODY), considering its distinction from stress hyperglycemia. Following the development of febrile seizures owing to adenovirus infection, the patient presented a casual blood glucose level was 185 mg/dL. She had a multigenerational family history of diabetes and a hemoglobin A1c (HbA1c) level of 6.4%. Owing to the persistent glucose intolerance until the age of 5 years, genetic testing was performed, which revealed a heterozygous mutation in GCK, and the patient was diagnosed with GCK-MODY. Precise diagnosis of GCK-MODY individuals is important to avoid administering unnecessary antidiabetic medications. Even during hyperglycemia under stress, multigenerational diabetes and mildly elevated HbA1c levels can suggest GCK-MODY.

引用

页码：72 / 75

页数：4

共 15 条

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