MBL2 gene polymorphisms related to HIV-1 infection susceptibility and treatment response

被引：2

作者：

Bouqdayr, Meryem ^{[1
,2
]}

Baba, Hana ^{[1
,2
]}

Saih, Asmae ^{[1
,2
]}

Abbad, Anass ^{[3
,4
]}

Hamdi, Salsabil ^{[5
]}

Marih, Latifa ^{[6
]}

Sodqi, Mustapha ^{[6
]}

Ouladlahsen, Ahd ^{[6
]}

El Filali, Kamal Marhoum ^{[6
]}

Moussamih, Samya ^{[7
]}

Saile, Rachid ^{[2
]}

Kettani, Anass ^{[2
]}

Wakrim, Lahcen ^{[1
]}

机构：

[1] Inst Pasteur Maroc, Virol Unit, Immunovirol Lab, Casablanca, Morocco

[2] Hassan II Univ Casablanca, Fac Sci Ben MSik, Lab Biol & Hlth, Casablanca, Morocco

[3] Inst Pasteur Maroc, Med Virol & BSL Lab 3, Casablanca, Morocco

[4] Hassan II Univ Casablanca, Fac Sci Ben MSik, Lab Ecol & Environm, Casablanca, Morocco

[5] Inst Pasteur Maroc, Environm Hlth Lab, Casablanca, Morocco

[6] CHU Ibn Rochd, Serv Malad Infect, Casablanca, Morocco

[7] Hassan II Univ Casablanca, Fac Sci Ain Chock, Lab Immunol & Biodivers, Casablanca, Morocco

来源：

HUMAN IMMUNOLOGY | 2023年 / 84卷 / 02期

关键词：

MBL2; gene; HIV-1; Polymorphisms; Infection susceptibility; Disease development; ART; MANNOSE-BINDING LECTIN; TO-CHILD TRANSMISSION; COMPLEMENT ACTIVATION; VERTICAL TRANSMISSION; AFRICAN POPULATIONS; DUAL ROLE; PROTEIN; ASSOCIATION; MUTATIONS; PROMOTER;

D O I：

10.1016/j.humimm.2022.09.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human Mannose-binding lectin (MBL) is a protein encoded by MBL2 gene involved in the activation of the lectin-complement pathway. Several studies emphasized the role of MBL2 gene in several infectious diseases' susceptibility, including HIV-1 infection. We aim to investigate the impact of 10 MBL2 gene polymorphisms located in the promoter, 50UTR and exon 1 regions on HIV-1 physiopathology. The polymorphisms genotyping of 400 individuals, which 200 were HIV-1 positive patients and 200 were controls, was performed by PCR-sequencing. Our results showed that rs503037 and rs1800451 polymorphisms are associated with a high risk of HIV-1 infection susceptibility while rs7096206 and rs11003123 showed a protective effect. A significant association between haplotype CGA and HIV-1 infection susceptibility was also found in the exon 1 region. Moreover, rs11003124, rs7084554, rs36014597 and rs11003123 polymorphisms revealed an association with treatment response outcome as measured by RNA viral load. This study highlights the importance of MBL2 polymorphisms in the modulation of HIV-1 infection susceptibility and the contribution to treatment response outcomes among Moroccan subjects.

引用

页码：80 / 88

页数：9