Abnormalities of EEG Functional Connectivity and Effective Connectivity in Children with Autism Spectrum Disorder

被引：11

作者：

Geng, Xinling ^{[1
]}

Fan, Xiwang ^{[2
]}

Zhong, Yiwen ^{[2
]}

Casanova, Manuel F. ^{[3
]}

Sokhadze, Estate M. ^{[3
]}

Li, Xiaoli ^{[4
]}

Kang, Jiannan ^{[5
]}

机构：

[1] Capital Med Univ, Sch Biomed Engn, Beijing 100069, Peoples R China

[2] Tongji Univ, Clin Res Ctr Mental Disorders, Shanghai Pudong New Area Mental Hlth Ctr, Sch Med, Shanghai 200124, Peoples R China

[3] Univ South Carolina, Dept Biomed Sci, Sch Med Greenville, 701 Grove Rd, Greenville, SC 29605 USA

[4] Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100859, Peoples R China

[5] Hebei Univ, Coll Elect & Informat Engn, Baoding 071000, Peoples R China

来源：

BRAIN SCIENCES | 2023年 / 13卷 / 01期

基金：

中国国家自然科学基金;

关键词：

autism spectrum disorder; EEG; functional connectivity; effective connectivity; INFANTS; SYNCHRONIZATION; INTEGRATION; INDEX; RISK;

D O I：

10.3390/brainsci13010130

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder that interferes with normal brain development. Brain connectivity may serve as a biomarker for ASD in this respect. This study enrolled a total of 179 children aged 3-10 years (90 typically developed (TD) and 89 with ASD). We used a weighted phase lag index and a directed transfer function to investigate the functional and effective connectivity in children with ASD and TD. Our findings indicated that patients with ASD had local hyper-connectivity of brain regions in functional connectivity and simultaneous significant decrease in effective connectivity across hemispheres. These connectivity abnormalities may help to find biomarkers of ASD.

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