Abnormalities of EEG Functional Connectivity and Effective Connectivity in Children with Autism Spectrum Disorder

被引：11
作者：
Geng, Xinling [1 ]
Fan, Xiwang [2 ]
Zhong, Yiwen [2 ]
Casanova, Manuel F. [3 ]
Sokhadze, Estate M. [3 ]
Li, Xiaoli [4 ]
Kang, Jiannan [5 ]
机构：
[1] Capital Med Univ, Sch Biomed Engn, Beijing 100069, Peoples R China
[2] Tongji Univ, Clin Res Ctr Mental Disorders, Shanghai Pudong New Area Mental Hlth Ctr, Sch Med, Shanghai 200124, Peoples R China
[3] Univ South Carolina, Dept Biomed Sci, Sch Med Greenville, 701 Grove Rd, Greenville, SC 29605 USA
[4] Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100859, Peoples R China
[5] Hebei Univ, Coll Elect & Informat Engn, Baoding 071000, Peoples R China
来源：
BRAIN SCIENCES | 2023年 / 13卷 / 01期
基金：
中国国家自然科学基金;
关键词：
autism spectrum disorder; EEG; functional connectivity; effective connectivity; INFANTS; SYNCHRONIZATION; INTEGRATION; INDEX; RISK;
D O I：
10.3390/brainsci13010130
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder that interferes with normal brain development. Brain connectivity may serve as a biomarker for ASD in this respect. This study enrolled a total of 179 children aged 3-10 years (90 typically developed (TD) and 89 with ASD). We used a weighted phase lag index and a directed transfer function to investigate the functional and effective connectivity in children with ASD and TD. Our findings indicated that patients with ASD had local hyper-connectivity of brain regions in functional connectivity and simultaneous significant decrease in effective connectivity across hemispheres. These connectivity abnormalities may help to find biomarkers of ASD.
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页数：12
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