Curved microchannels with inner wall expansion-contraction array for particle focusing

被引:2
|
作者
Zhuang, Ruihan [1 ,2 ]
Song, Kaixin [1 ,2 ]
Wang, Zhibin [1 ,2 ,3 ]
Chen, Gang [4 ]
Chen, Ying [1 ,2 ]
Jia, Lisi [1 ,2 ]
机构
[1] Guangdong Univ Technol, Sch Mat & Energy, Guangzhou 510006, Peoples R China
[2] Guangdong Prov Key Lab Funct Soft Condensed Matter, Guangzhou 510006, Peoples R China
[3] Chongqing Univ, Key Lab Low grade Energy Utilizat Technol & Syst, Minist Educ China, Chongqing 400044, Peoples R China
[4] Zhengzhou Univ Light Ind, Sch Energy & Power Engn, Zhengzhou 450002, Henan, Peoples R China
基金
中国国家自然科学基金;
关键词
Inertial focusing; Curved microchannel; Expansion-contraction array; Multi-Dean flow; INERTIAL MICROFLUIDICS; SPIRAL MICROCHANNEL; FLOW; CELLS;
D O I
10.1007/s10404-024-02715-1
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
To enhance focusing performance, we proposed an integrated microchannel with expansion-contraction arrays (ECA) on the inner wall of the curved microchannel (CIECA) and compared it with a straight microchannel with ECA (SECA) as well as the traditional integrated microchannel of ECA on the outer wall of the curved channel (COECA). We investigated the particle-focusing mechanisms in these microchannels through a combination of experiments and numerical simulations. The proposed integrated microchannel demonstrates significant improvements in focusing performance compared to SECA and COECA, which is attributed to its consistent Dean flow. In contrast, COECA shows the poorest performance because of inconsistent Dean flow. The focusing width in the proposed integrated microchannel is reduced to 1/3 of that in COECA and 1/2 of that in SECA. Furthermore, the focusing performance of CIECA improves as the Reynolds number increases, eventually forming a single trajectory when the Reynolds number (at contraction) reaches 83.33. Finally, the impact of particle size on focusing performance was investigated through numerical simulations. The focusing performance of the CIECA is the best in these three microchannels. In CIECA, as the particle size increases, the focusing width initially decreases and then increases. Among them, 8 and 10 mu m particles can achieve complete focusing. This study serves as a crucial reference for comprehending and enhancing particle focusing through the synergy of multi-Dean flow.
引用
收藏
页数:16
相关论文
共 9 条
  • [1] Curved microchannels with inner wall expansion–contraction array for particle focusing
    Ruihan Zhuang
    Kaixin Song
    Zhibin Wang
    Gang Chen
    Ying Chen
    Lisi Jia
    Microfluidics and Nanofluidics, 2024, 28
  • [2] Synergistically enhancing inertial particle focusing using a curved microchannel with expansion-contraction arrays
    Zhuang, Ruihan
    Zhang, Jionglong
    Chen, Gang
    Wang, Zhibin
    Jia, Lisi
    Chen, Ying
    PARTICUOLOGY, 2025, 98 : 83 - 93
  • [3] Inertial focusing and filtration of microparticles with expansion-contraction structures in microchannel
    Dar, Skinder Ali
    Yeh, Szu-I.
    MICROFLUIDICS AND NANOFLUIDICS, 2022, 26 (06)
  • [4] Experimental study on inertial focusing pattern in asymmetric contraction-expansion array microchannel
    Zhu, Guorui
    Zhang, Ziqian
    Shi, Xin
    Tan, Wei
    MICROFLUIDICS AND NANOFLUIDICS, 2022, 26 (01)
  • [5] A curved expansion-contraction microfluidic structure for inertial based separation of circulating tumor cells from blood samples
    Ebrahimi, Sina
    Alishiri, Mojgan
    Pishbin, Esmail
    Afjoul, Homa
    Shamloo, Amir
    JOURNAL OF CHROMATOGRAPHY A, 2023, 1705
  • [6] Numerical simulation of particle migration in different contraction-expansion ratio microchannels
    Jiang, Di
    Huang, Di
    Zhao, Gutian
    Tang, Wenlai
    Xiang, Nan
    MICROFLUIDICS AND NANOFLUIDICS, 2019, 23 (01)
  • [7] Enhanced particle focusing and sorting by multiple sheath stream in contraction-expansion microchannel
    Wang, Zhibin
    Zhen, Tieshan
    Wu, Fan
    Mo, Songping
    Jia, Lisi
    Chen, Ying
    MICROFLUIDICS AND NANOFLUIDICS, 2023, 27 (02)
  • [8] Coupling Contraction-expansion Arrays with Spiral Microchannels to Enhance Microfluidic-Based Particle/Cell Separation
    Shahraki, Zahra Hashemi
    Navidbakhsh, Mahdi
    Taylor, Robert A.
    INTERNATIONAL JOURNAL OF COMPUTATIONAL FLUID DYNAMICS, 2022, 36 (01) : 63 - 90
  • [9] Experiment study on focusing pattern prediction of particles in asymmetric contraction-expansion array channel
    Shi, Xin
    He, Qing
    Tan, Wei
    Lu, Yuwen
    Zhu, Guorui
    ELECTROPHORESIS, 2024, 45 (23-24) : 2169 - 2181