Altered Intrinsic Brain Spontaneous Activities in Children With Autism Spectrum Disorder Comorbid ADHD

被引：0
作者：
Tang, Xinzhou [1 ,2 ]
Ma, Zenghui [1 ]
Siuching, Kat [1 ]
Xu, Lingzi [1 ]
Liu, Qinyi [1 ]
Yang, Li [1 ]
Wang, Yufeng [1 ]
Cao, Qingjiu [1 ,3 ]
Li, Xue [1 ,3 ]
Liu, Jing [1 ,3 ]
机构：
[1] Peking Univ Sixth Hosp, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China
[2] China Natl Childrens Hlth Ctr, Beijing, Peoples R China
[3] Peking Univ Sixth Hosp, Inst Mental Hlth, Natl Clin Res Ctr Mental Disorders, 51 Huayuan Rd, Beijing 100191, Peoples R China
来源：
JOURNAL OF ATTENTION DISORDERS | 2024年 / 28卷 / 05期
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
autism spectrum disorder; ADHD; comorbidity; amplitude of low-frequency fluctuations; fnctional connectivity; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; ABNORMAL FUNCTIONAL CONNECTIVITY; NETWORK CONNECTIVITY; GLOBAL SIGNAL; FRONTAL GYRUS; FMRI; ADOLESCENTS; SYMPTOMS; CORTEX; TRAITS;
D O I：
10.1177/10870547241233207
中图分类号：
B844 [发展心理学（人类心理学）];
学科分类号：
040202 ;
摘要：
Objective: The study involved 17 children with Autism Spectrum Disorder (ASD), 21 with ADHD, 30 with both (ASD + ADHD), and 28 typically developing children (TD).Methods: The amplitude of low-frequency fluctuations (ALFF) was measured as a regional brain function index. Intrinsic functional connectivity (iFC) was also analyzed using the region of interest (ROI) identified in ALFF analysis. Statistical analysis was done via one-way ANCOVA, Gaussian random field (GRF) theory, and post-hoc pair-wise comparisons.Results: The ASD + ADHD group showed increased ALFF in the left middle frontal gyrus (MFG.L) compared to the TD group. In terms of global brain function, the ASD group displayed underconnectivity in specific regions compared to the ASD + ADHD and TD groups.Conclusion: The findings contribute to understanding the neural mechanisms underlying ASD + ADHD.
引用
收藏
页码：834 / 846
页数：13
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