Triglyceride-Glucose Index as a Predictor of Lower Extremity Arterial Disease in Patients with Diabetes: A Hospitalized Population Retrospective Study

被引:2
作者
Ning, Peng [1 ]
Zeng, Jing [1 ]
Feng, Qiu [1 ]
Chen, Min [1 ]
Cao, Hongyi [1 ,2 ]
机构
[1] Chengdu Univ Tradit Chinese Med, Chengdu Peoples Hosp 5, Clin Med Coll 2, Dept Endocrine & Metab,Affiliated Peoples Hosp 5, Chengdu, Sichuan, Romania
[2] Chengdu Fifth Peoples Hosp, Dept Endocrine & Metab, Chengdu 610000, Sichuan, Peoples R China
关键词
INSULIN-RESISTANCE; HIGH-RISK; TYPE-2; PREVALENCE; AMPUTATION; SEX;
D O I
10.1016/j.avsg.2023.08.013
中图分类号
R61 [外科手术学];
学科分类号
摘要
Background: The triglyceride-glucose (TyG) index is a new, simple, and inexpensive marker of insulin resistance that is becoming increasingly important as a promising predictor of diseases such as atherosclerosis. Atherosclerosis is the main cause of lower extremity arterial disease (LEAD). In this study, we investigated the relationship between TyG index values and LEAD risk in patients with diabetes.Methods: Patients with diabetes hospitalized at the Endocrinology Department of our hospital from June 1, 2021, to May 31, 2022, were retrospectively included. Baseline data, biochemical indicators, and ankle-brachial index values were collected. Statistical methods were used to assess the relationship between TyG index values and the risk of LEAD.Results: A total of 1,040 hospitalized patients with diabetes were included, they were divided into the LEAD group with 168 patients and the no LEAD group with 872 patients. TyG index values in the LEAD group were higher than those in the no LEAD group (9.94 +/- 0.78 vs. 9.36 +/- 0.70, P < 0.001). TyG index values were independently correlated with LEAD risk in patients with diabetes (odds ratio = 3.92, 95% confidence interval (CI): 2.92-5.26, P < 0.001) in multivariate logistic regression analysis after adjusting for different risk factors (all P < 0.05). The area under the receiver operating characteristic curve was 0.72 (95% CI: 0.68-0.76) when TyG index values were used to diagnose LEAD in patients with diabetes. When Youden's index reached the maximum value of 0.34, the optimal TyG index threshold for predicting the onset of diabetic LEAD was 9.56, sensitivity was 71.1%, and specificity was 63.0%.Conclusions: Increases in TyG index values were associated with the risk of LEAD in patients with diabetes and, thus, may be used as a predictor of LEAD in this patient population, especially in primary care institutions with relatively few resources.
引用
收藏
页码:173 / 181
页数:9
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