The Role of Galectin-3 in Retinal Degeneration and Other Ocular Diseases: A Potential Novel Biomarker and Therapeutic Target

被引：4

作者：

Zhou, Ziyi ^{[1
]}

Feng, Zhaochen ^{[1
]}

Sun, Xiaojia ^{[1
]}

Wang, Yusheng ^{[1
]}

Dou, Guorui ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Xijing Hosp, Eye Inst Chinese PLA, Dept Ophthalmol, Xian 710032, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 21期

基金：

中国国家自然科学基金;

关键词：

galectin-3; retinal degeneration; molecular mechanisms; diagnostics; molecular therapy; CELL-ADHESION MOLECULES; TUMOR PROGRESSION; PATHOLOGICAL ANGIOGENESIS; MYOCARDIAL-INFARCTION; MICROGLIA ACTIVATION; MACULAR DEGENERATION; EXTRACELLULAR-MATRIX; ANIMAL LECTINS; AQUEOUS-HUMOR; EXPRESSION;

D O I：

10.3390/ijms242115516

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Galectin-3 is the most studied member of the Galectin family, with a large range of mediation in biological activities such as cell growth, proliferation, apoptosis, differentiation, cell adhesion, and tissue repair, as well as in pathological processes such as inflammation, tissue fibrosis, and angiogenesis. As is known to all, inflammation, aberrant cell apoptosis, and neovascularization are the main pathophysiological processes in retinal degeneration and many ocular diseases. Therefore, the review aims to conclude the role of Gal3 in the retinal degeneration of various diseases as well as the occurrence and development of the diseases and discuss its molecular mechanisms according to research in systemic diseases. At the same time, we summarized the predictive role of Gal3 as a biomarker and the clinical application of its inhibitors to discuss the possibility of Gal3 as a novel target for the treatment of ocular diseases.

引用

页数：19

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