Rethinking the definition of 'less intensive' for venetoclax-combining regimens in acute myeloid leukaemia patients

被引：0
作者：
Borlenghi, E. [1 ]
Roccaro, A. M. [2 ]
Cattaneo, C. [1 ,3 ]
机构：
[1] ASST Spedali Civili, Hematol, Brescia, Italy
[2] ASST Spedali Civili, Translat Res & Phase Unit 1, Clin Trial Ctr, Brescia, Italy
[3] ASST Spedali Civili, Hematol, I-25123 Brescia, Italy
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2023年 / 203卷 / 04期
关键词：
acute myeloid leukaemia; invasive fungal infections; myelodysplastic syndromes; posaconazole; venetoclax;
D O I：
10.1111/bjh.19138
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Invasive fungal infections (IFIs), mainly due to pulmonary aspergillosis, are considered a serious complication in acute leukaemia, with an unfavourable impact on patient. In this well-conducted retrospective study, Reynolds et al. suggest that the use of posaconazole prophylaxis in association with venetoclax plus hypomethylating agents or chemotherapy leads to a reduction of IFI incidence. Therapeutic drug monitoring of posaconazole levels is suggested, even if no correlation with IFI risk has been demonstrated.
引用
收藏
页码：504 / 506
页数：3
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