Rethinking the definition of 'less intensive' for venetoclax-combining regimens in acute myeloid leukaemia patients

被引：0
|
作者：
Borlenghi, E. [1 ]
Roccaro, A. M. [2 ]
Cattaneo, C. [1 ,3 ]
机构：
[1] ASST Spedali Civili, Hematol, Brescia, Italy
[2] ASST Spedali Civili, Translat Res & Phase Unit 1, Clin Trial Ctr, Brescia, Italy
[3] ASST Spedali Civili, Hematol, I-25123 Brescia, Italy
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2023年 / 203卷 / 04期
关键词：
acute myeloid leukaemia; invasive fungal infections; myelodysplastic syndromes; posaconazole; venetoclax;
D O I：
10.1111/bjh.19138
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Invasive fungal infections (IFIs), mainly due to pulmonary aspergillosis, are considered a serious complication in acute leukaemia, with an unfavourable impact on patient. In this well-conducted retrospective study, Reynolds et al. suggest that the use of posaconazole prophylaxis in association with venetoclax plus hypomethylating agents or chemotherapy leads to a reduction of IFI incidence. Therapeutic drug monitoring of posaconazole levels is suggested, even if no correlation with IFI risk has been demonstrated.
引用
收藏
页码：504 / 506
页数：3
相关论文
共 50 条
  • [1] Characterisation of infections in patients with acute myeloid leukaemia receiving venetoclax and a hypomethylating agent
    On, Sandy
    Rath, Carolyn G.
    Lan, Michelle
    Wu, Bobby
    Lau, Kimberly M.
    Cheung, Edna
    Alegria, William
    Young, Rebecca
    Tan, Marisela
    Kim, Carrie
    Phun, Jennifer
    Patel, Nimish
    Mannis, Gabriel
    Logan, Aaron C.
    Kennedy, Vanessa
    Goodman, Aaron
    Taplitz, Randy A.
    Young, Patricia A.
    Wen, Raymond
    Saunders, Ila M.
    BRITISH JOURNAL OF HAEMATOLOGY, 2022, 197 (01) : 63 - 70
  • [2] Venetoclax plus low-dose cytarabine in Japanese patients with untreated acute myeloid leukaemia ineligible for intensive chemotherapy
    Yamauchi, Takahiro
    Yoshida, Chikashi
    Usuki, Kensuke
    Takada, Satoru
    Matsumura, Itaru
    Dobashi, Nobuaki
    Miyazaki, Yasushi
    Miyamoto, Toshihiro
    Iida, Hiroatsu
    Asou, Norio
    Kuroda, Junya
    Ichikawa, Satoshi
    Komatsu, Norio
    Mendes, Wellington
    Honda, Hideyuki
    Okubo, Sumiko
    Kurokawa, Misaki
    Jiang, Qi
    Wei, Andrew
    Ishizawa, Kenichi
    JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2021, 51 (09) : 1372 - 1382
  • [3] Venetoclax-based therapy for relapsed or refractory acute myeloid leukaemia following intensive induction chemotherapy
    Kristensen, Daniel Tuyet
    Brondum, Rasmus Froberg
    orskov, Andreas Due
    Marcher, Claus Werenberg
    Schollkopf, Claudia
    Sorensen, Anne Louise Tolboll
    Severinsen, Marianne Tang
    Bogsted, Martin
    Roug, Anne Stidsholt
    EUROPEAN JOURNAL OF HAEMATOLOGY, 2023, 111 (04) : 573 - 582
  • [4] Pityriasiform drug eruption associated with venetoclax for acute myeloid leukaemia
    Liu, Timothy J.
    McMeniman, Erin K.
    ANTI-CANCER DRUGS, 2024, 35 (07) : 641 - 643
  • [5] Hypomethylating agent/venetoclax versus intensive chemotherapy in adults with relapsed or refractory acute myeloid leukaemia
    Jamy, Omer
    Lin, Karen
    Worth, Sarah
    Bachiashvili, Kimo
    Rangaraju, Sravanti
    Vachhani, Pankit
    Bhatia, Ravi
    BRITISH JOURNAL OF HAEMATOLOGY, 2022, 198 (03) : E35 - E37
  • [6] Venetoclax-containing regimens in acute myeloid leukemia
    Aldoss, Ibrahim
    Pullarkat, Vinod
    Stein, Anthony S.
    THERAPEUTIC ADVANCES IN HEMATOLOGY, 2021, 12
  • [7] Venetoclax resistance in acute myeloid leukaemia-Clinical and biological insights
    Nachmias, Boaz
    Aumann, Shlomzion
    Haran, Arnon
    Schimmer, Aaron D.
    BRITISH JOURNAL OF HAEMATOLOGY, 2024, 204 (04) : 1146 - 1158
  • [8] Prognosis of patients with acute myeloid leukaemia admitted to intensive care
    Rabbat, A
    Chaoui, D
    Montani, D
    Legrand, O
    Lefebvre, A
    Rio, B
    Roche, N
    Lorut, C
    Marie, JP
    Huchon, G
    BRITISH JOURNAL OF HAEMATOLOGY, 2005, 129 (03) : 350 - 357
  • [9] Venetoclax and hypomethylating agents in TP53-mutated acute myeloid leukaemia
    Aldoss, Ibrahim
    Zhang, Jianying
    Pillai, Raju
    Shouse, Geoffrey
    Sanchez, James F.
    Mei, Matthew
    Nakamura, Ryotaro
    Stein, Anthony S.
    Forman, Stephen J.
    Marcucci, Guido
    Pullarkat, Vinod
    BRITISH JOURNAL OF HAEMATOLOGY, 2019, 187 (02) : E45 - E48
  • [10] Should patients with acute myeloid leukemia treated with venetoclax-based regimens receive antifungal prophylaxis?
    Guarana, Mariana
    Nucci, Marcio
    LEUKEMIA RESEARCH, 2023, 131
12345