Viable but nonculturable (VBNC) state, an underestimated and controversial microbial survival strategy

被引：77
作者：
Liu, Junyan [1 ,2 ]
Yang, Liang [3 ]
Kjellerup, Birthe Veno [4 ]
Xu, Zhenbo [5 ,6 ]
机构：
[1] Zhongkai Univ Agr & Engn, Acad Con orary Agr Engn Innovat, Coll Light Ind & Food Sci, Guangdong Prov Key Lab Lingnan Specialty Food Sci, Guangzhou 510225, Peoples R China
[2] Key Lab Green Proc & Intelligent Mfg Lingnan Speci, Minist Agr, Guangzhou 510225, Peoples R China
[3] Southern Univ Sci & Technol, Sch Med, Shenzhen 518055, Peoples R China
[4] Univ Maryland, Dept Civil & Environm Engn, College Pk, MD 20742 USA
[5] South China Univ Technol, Engn Res Ctr Starch & Vegetable Prot Proc, Guangdong Prov Key Lab Green Proc Nat Prod & Prod, Sch Food Sci & Engn,Minist Educ, Guangzhou 510640, Peoples R China
[6] Shantou Univ, Affiliated Hosp 2, Med Coll, Dept Lab Med, Shantou, Peoples R China
来源：
TRENDS IN MICROBIOLOGY | 2023年 / 31卷 / 10期
基金：
中国国家自然科学基金;
关键词：
NON-CULTURABLE STATE; ESCHERICHIA-COLI; VIBRIO-CHOLERAE; SPOILAGE CAPABILITY; VIABILITY; RESUSCITATION; DISINFECTION; BIOFILMS; CELLS; SPP;
D O I：
10.1016/j.tim.2023.04.009
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
As a unique microbial response to adverse circumstances, the viable but nonculturable (VBNC) state is characterized by the loss of culturability of microbial cells on/in nutrient media that normally support their growth, while maintaining metabolic activity. These cells can resuscitate to a culturable state under suitable conditions. Given the intrinsic importance of the VBNC state and recent debates surrounding it, there is a need to redefine and standardize the term, and to address essential questions such as 'How to differentiate VBNC from other similar terms?' and 'How can VBNC cells be standardly and accurately determined?'. This opinion piece aims at contributing to an improved understanding of the VBNC state and promoting its proper handling as an underestimated and controversial microbial survival strategy.
引用
收藏
页码：1013 / 1023
页数：11
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