Differences in the prevalence and clinical correlates of comorbid suicide attempts in patients with early- and late-onset major depressive disorder

被引:2
作者
Huang, Xiao [1 ]
Sun, Yuan [2 ]
Wu, Anshi [1 ]
Zhang, Xiangyang [3 ,4 ]
机构
[1] Capital Med Univ, Beijing Chao Yang Hosp, Dept Anesthesiol, Beijing, Peoples R China
[2] Capital Med Univ, Beijing Chao Yang Hosp, Dept Pharm, Beijing, Peoples R China
[3] Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
[4] Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
关键词
MDD (major depressive disorder); suicide attempts; age at onset; prevalence; outpatients; GLOBAL BURDEN; AGE; IDEATION; DISEASE; FEATURES; CHINA;
D O I
10.3389/fpsyt.2023.1173917
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
ObjectiveThere are many studies on differences in the onset age of major depressive disorder (MDD) patients. However, study on differences in clinical correlates of suicide attempts between early- and late-onset MDD patients is limited. The aim of this study was to investigate the differences in the prevalence and clinical correlates of suicide attempts in patients with early- and late-onset MDD in China. MethodsA total of 1718 adult outpatients with MDD were recruited. Demographic and clinical data were collected. The 17-item Hamilton Rating Scale for Depression (HAMD-17), Hamilton Anxiety Rating Scale (HAMA), Positive and Negative Syndrome Scale (PANSS) positive subscale, and Clinical Global Impression-Severity (CGI-S) Scales were used to assess their depressive, anxiety, psychotic symptoms, and the severity of the clinical symptoms, respectively. ResultsThe prevalence of suicide attempts was higher in late-onset MDD patients (291/1369, 21.3%) than in early-onset MDD patients (55/349, 15.8%) (p = 0.023). However after Bonferroni correction no significant difference was found in the prevalence of suicide attempts in late-onset and late-onset MDD patients (p > 0.05). In both early- and late-onset groups, univariate analysis showed that the following characteristics were significantly associated with suicide attempts: HAMA, HAMD and PANSS positive subscale scores, thyroid stimulating hormone (TSH) levels, blood glucose levels, systolic blood pressure (SBP), and diastolic blood pressure (DBP). In both the early- and late-onset groups, the prevalence rates of severe anxiety disorder and psychotic symptoms were significantly higher in the suicide attempt group than in the non-suicide attempt group. In regression analysis, disease duration, TSH levels and HAMA score were independently associated with suicide attempts in the early-onset group, while TSH levels, HAMA and HAMD score were independently associated with suicide attempts in the late-onset group. ConclusionThis study suggests that suicide attempts are not frequent in early-onset outpatients with MDD compared with late-onset, and some clinical correlates are associated with suicide attempt in early- and late-onset MDD.
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页数:8
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