Analysis and validation of overall N-glycan conformation in Privateer

被引：9
|
作者：
Dialpuri, Jordan S. [1 ]
Bagdonas, Haroldas [1 ]
Atanasova, Mihaela [1 ]
Schofield, Lucy C. [1 ]
Hekkelman, Maarten L. [2 ,3 ]
Joosten, Robbie P. [2 ,3 ]
Agirre, Jon [1 ]
机构：
[1] Univ York, Dept Chem, York Struct Biol Lab, York YO10 5DD, N Yorkshire, England
[2] Netherlands Canc Inst, Oncode Inst, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands
[3] Netherlands Canc Inst, Div Biochem, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands
来源：
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY | 2023年 / 79卷
基金：
英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;
关键词：
glycobiology; validation; Privateer; N-glycans; torsion angles; CARBOHYDRATE STRUCTURE; CRYSTAL-STRUCTURE; PROTEIN; COMPLEX; GLYCOSYLATION;
D O I：
10.1107/S2059798323003510
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The oligosaccharides in N-glycosylation provide key structural and functional contributions to a glycoprotein. These contributions are dependent on the composition and overall conformation of the glycans. The Privateer software allows structural biologists to evaluate and improve the atomic structures of carbohydrates, including N-glycans; this software has recently been extended to check glycan composition through the use of glycomics data. Here, a broadening of the scope of the software to analyse and validate the overall conformation of N-glycans is presented, focusing on a newly compiled set of glycosidic linkage torsional preferences harvested from a curated set of glycoprotein models.
引用
收藏
页码：462 / 472
页数：11
相关论文
共 50 条
  • [41] Synthesis of N-glycan units for assessment of substrate structural requirements of N-acetylglucosaminyltransferase III
    Hanashima, Shinya
    Korekane, Hiroaki
    Taniguchi, Naoyuki
    Yamaguchi, Yoshiki
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (18) : 4533 - 4537
  • [42] Glycoblotting of Egg White Reveals Diverse N-Glycan Expression in Quail Species
    Sanes, Jurgen T.
    Hinou, Hiroshi
    Lee, Yuan Chuan
    Nishimura, Shin-Ichiro
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2019, 67 (01) : 531 - 540
  • [43] CRISPR screens and lectin microarrays identify high mannose N-glycan regulators
    Tsui, C. Kimberly
    Twells, Nicholas
    Durieux, Jenni
    Doan, Emma
    Woo, Jacqueline
    Khosrojerdi, Noosha
    Brooks, Janiya
    Kulepa, Ayodeji
    Webster, Brant
    Mahal, Lara K.
    Dillin, Andrew
    NATURE COMMUNICATIONS, 2024, 15 (01)
  • [44] N-Glycosylation and N-Glycan Processing in HBV Biology and Pathogenesis
    Dobrica, Mihaela-Olivia
    Lazar, Catalin
    Branza-Nichita, Norica
    CELLS, 2020, 9 (06) : 1 - 15
  • [45] Mechanism of high-mannose N-glycan breakdown and metabolism by Bifidobacterium longum
    Cordeiro, Rosa L.
    Santos, Camila R.
    Domingues, Mariane N.
    Lima, Tatiani B.
    Pirolla, Renan A. S.
    Morais, Mariana A. B.
    Colombari, Felippe M.
    Miyamoto, Renan Y.
    Persinoti, Gabriela F.
    Borges, Antonio C.
    de Farias, Marcelo A.
    Stoffel, Fabiane
    Li, Chao
    Gozzo, Fabio C.
    van Heel, Marin
    Guerin, Marcelo E.
    Sundberg, Eric J.
    Wang, Lai-Xi
    Portugal, Rodrigo V.
    Giuseppe, Priscila O.
    Murakami, Mario T.
    NATURE CHEMICAL BIOLOGY, 2023, 19 (02) : 218 - +
  • [46] Multistage mass spectrometry with intelligent precursor selection for N-glycan branching pattern analysis
    Huang, Chuncui
    Wang, Hui
    Bu, Dongbo
    Zhou, Jinyu
    Dong, Junchuan
    Zhang, Jingwei
    Gao, Huanyu
    Wang, Yaojun
    Chai, Wengang
    Sun, Shiwei
    Li, Yan
    CARBOHYDRATE POLYMERS, 2020, 237
  • [47] Purification free N-glycan analysis by capillary zone electrophoresis: Hunt for the lost glycans
    Farsang, Robert
    Jarvas, Gabor
    Guttman, Andras
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2024, 238
  • [48] High-throughput quantitative analysis of plant N-glycan using a DNA sequencer
    Lee, Kyung Jin
    Jung, Jin-Hee
    Lee, Jung Mi
    So, Yangkang
    Kwon, Ohsuk
    Callewaert, Nico
    Kang, Hyun Ah
    Ko, Kisung
    Oh, Doo-Byoung
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 380 (02) : 223 - 229
  • [49] N-glycan analysis of mannose/glucose specific lectin from Dolichos lablab seeds
    Kumar, Gnanesh B. S.
    Pohlentz, Gottfried
    Schulte, Mona
    Mormann, Michael
    Nadimpalli, Siva Kumar
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2014, 69 : 400 - 407
  • [50] Restricted Motion of the Conserved Immunoglobulin G1 N-Glycan Is Essential for Efficient FcγRIIIa Binding
    Subedi, Ganesh P.
    Hanson, Quinlin M.
    Barb, Adam W.
    STRUCTURE, 2014, 22 (10) : 1478 - 1488
12345