The Reactions of p-Tosylmethyl Isocyanide with Aldehydes in the Synthesis of Heterocyclic Compounds: A Review

被引：0

作者：

Vchislo, Nadezhda V. ^{[1
]}

Fedoseeva, Victoria G. ^{[1
]}

Verochkina, Ekaterina A. ^{[1
]}

机构：

[1] Russian Acad Sci, AE Favorsky Irkutsk Inst Chem, Siberian Branch, 1 Favorsky St, Irkutsk 664033, Russia

来源：

MINI-REVIEWS IN ORGANIC CHEMISTRY | 2023年 / 20卷 / 04期

关键词：

Aldehydes; p-tosylmethyl isocyanide; heterocycles; cycloaddition; catalysis; natural products; ONE-POT SYNTHESIS; 3,4-DISUBSTITUTED PYRROLES; MULTICOMPONENT REACTIONS; POLYSUBSTITUTED FURANS; PHOTOCHEMICAL APPROACH; CATALYZED SYNTHESIS; NATURAL-PRODUCTS; FACILE SYNTHESIS; SMALL-MOLECULE; IN-SILICO;

D O I：

10.2174/1570193X19999220523113243

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

p-Tosylmethyl isocyanide (TosMIC) and its derivatives represent an important class of polyfunctional reagents, making them privileged "building blocks" in the targeted organic synthesis to design a plethora of heterocycles as well as natural products. This review summarizes and highlights the synthetic potential of p-tosylmethyl isocyanide and its derivatives in the reaction with various aldehydes to afford valuable heterocycles. The catalytic and technological innovations discussed in the review reveal the ease of reaction. Moreover, their mechanistic schemes are also displayed.

引用

页码：372 / 393

页数：22

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