Theranostic Nanoprobes with Aggregation-Induced NIR-II Emission: from Molecular Design to Biomedical Application

被引：7
作者：
Jiang, Yajing [1 ]
Zhu, Linlin [1 ]
Wu, Wenbo [1 ]
机构：
[1] Tianjin Univ, Inst Mol Aggregat Sci, Dept Chem, Tianjin 300072, Peoples R China
来源：
CHEMBIOCHEM | 2023年
基金：
中国国家自然科学基金;
关键词：
aggregation-induced emission; nanoprobes; phototherapy; theranostics; the second near-infrared window; PHOTODYNAMIC THERAPY; ORGANIC NANOPARTICLES; CARBON NANOTUBES; AIE DOTS; PHOTOSENSITIZERS; FLUOROPHORES; FLUORESCENCE; VISUALIZATION; SIZE; CELL;
D O I：
10.1002/cbic.202200777
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The development of fluorophores with other powerful features has received much attention for the diagnosis and treatment of diseases. Nanoprobes (NPs) with aggregation-induced emission (AIE) have demonstrated superior performance in deeper penetration depth with better resolution, higher signal-to-noise ratio, and lower side effects in the second near-infrared window (NIR-II, 1000-1700 nm) than in any other range. Herein, the latest advances in NIR-II AIE NPs in cancer theranostics are summarized. In particular, we focus on the design of multifunctional AIE agents with both strong NIR-II emission and effective photothermal conversion or reactive oxygen species (ROS) production, as well as their translational biomedical applications, including imaging diagnosis, image-guided surgery, and image-guided phototherapy, etc. At the end of this review, the opportunities and challenges of this field are also discussed.
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页数：20
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