Theranostic Nanoprobes with Aggregation-Induced NIR-II Emission: from Molecular Design to Biomedical Application

被引：7

作者：

Jiang, Yajing ^{[1
]}

Zhu, Linlin ^{[1
]}

Wu, Wenbo ^{[1
]}

机构：

[1] Tianjin Univ, Inst Mol Aggregat Sci, Dept Chem, Tianjin 300072, Peoples R China

来源：

CHEMBIOCHEM | 2023年

基金：

中国国家自然科学基金;

关键词：

aggregation-induced emission; nanoprobes; phototherapy; theranostics; the second near-infrared window; PHOTODYNAMIC THERAPY; ORGANIC NANOPARTICLES; CARBON NANOTUBES; AIE DOTS; PHOTOSENSITIZERS; FLUOROPHORES; FLUORESCENCE; VISUALIZATION; SIZE; CELL;

D O I：

10.1002/cbic.202200777

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The development of fluorophores with other powerful features has received much attention for the diagnosis and treatment of diseases. Nanoprobes (NPs) with aggregation-induced emission (AIE) have demonstrated superior performance in deeper penetration depth with better resolution, higher signal-to-noise ratio, and lower side effects in the second near-infrared window (NIR-II, 1000-1700 nm) than in any other range. Herein, the latest advances in NIR-II AIE NPs in cancer theranostics are summarized. In particular, we focus on the design of multifunctional AIE agents with both strong NIR-II emission and effective photothermal conversion or reactive oxygen species (ROS) production, as well as their translational biomedical applications, including imaging diagnosis, image-guided surgery, and image-guided phototherapy, etc. At the end of this review, the opportunities and challenges of this field are also discussed.

引用

页数：20

共 114 条

[1] Single-Molecular Near-Infrared-II Theranostic Systems: Ultrastable Aggregation-Induced Emission Nanoparticles for Long-Term Tracing and Efficient Photothermal Therapy [J].

Alifu, Nuernisha ;

Zebibula, Abudureheman ;

Qi, Ji ;

Zhang, Hequn ;

Sun, Chaowei ;

Yu, Xiaoming ;

Xue, Dingwei ;

Lam, Jacky W. Y. ;

Li, Gonghui ;

Qian, Jun ;

Tang, Ben Zhong .

ACS NANO, 2018, 12 (11) :11282-11293

[2]

[Anonymous], 2019, ANGEW CHEM, V131, P19157

[3]

[Anonymous], 2021, ANGEW CHEM, V133, P26973

[4]

[Anonymous], 2020, ANGEW CHEM, V132, P3720

[5] Local structural motifs in proteins: Detection and characterization of fragments inserted in helices [J].

Balasco, Nicole ;

Smaldone, Giovanni ;

Ruggiero, Alessia ;

De Simone, Alfonso ;

Vitagliano, Luigi .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 118 :1924-1930

[6] PHOTOSENSITIZERS OF THE PORPHYRIN AND PHTHALOCYANINE SERIES FOR PHOTODYNAMIC THERAPY [J].

BONNETT, R .

CHEMICAL SOCIETY REVIEWS, 1995, 24 (01) :19-33

[7] Tuning Size and Morphology of mPEG-b-p(HPMA-Bz) Copolymer Self-Assemblies Using Microfluidics [J].

Bresseleers, Jaleesa ;

Bagheri, Mahsa ;

Lebleu, Coralie ;

Lecommandoux, Sebastien ;

Sandre, Olivier ;

Pijpers, Imke A. B. ;

Mason, Alexander F. ;

Meeuwissen, Silvie ;

Nostrum, Cornelus F. van ;

Hennink, Wim E. ;

Hest, Jan C. M. van .

POLYMERS, 2020, 12 (11) :1-18

[8] Multifunctional Liposome: A Bright AIEgen-Lipid Conjugate with Strong Photosensitization [J].

Cai, Xiaolei ;

Mao, Duo ;

Wang, Can ;

Kong, Deling ;

Cheng, Xiamin ;

Liu, Bin .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2018, 57 (50) :16396-16400

[9] Biocompatible Red Fluorescent Organic Nanoparticles with Tunable Size and Aggregation-Induced Emission for Evaluation of Blood-Brain Barrier Damage [J].

Cai, Xiaolei ;

Bandla, Aishwarya ;

Mao, Duo ;

Feng, Guangxue ;

Qin, Wei ;

Liao, Lun-De ;

Thakor, Nitish ;

Tang, Ben Zhong ;

Liu, Bin .

ADVANCED MATERIALS, 2016, 28 (39) :8760-8765

[10]

Chen FJ, 2022, SMALL, V18, DOI [10.1002/smll.202104402, 10.1002/smll.202203066]

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