The heterogeneity of cellular senescence: insights at the single-cell level

被引：124

作者：

Cohn, Rachel L. ^{[1
,2
]}

Gasek, Nathan S. ^{[1
,2
]}

Kuchel, George A. ^{[1
]}

Xu, Ming ^{[1
,2
]}

机构：

[1] UConn Hlth, UConn Ctr Aging, Farmington, CT 06030 USA

[2] UConn Hlth, Dept Genet & Genome Sci, Farmington, CT 06030 USA

来源：

TRENDS IN CELL BIOLOGY | 2023年 / 33卷 / 01期

基金：

美国国家卫生研究院;

关键词：

GENE-EXPRESSION; MOUSE; CLEARANCE;

D O I：

10.1016/j.tcb.2022.04.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Senescent cells are highly associated with aging and pathological conditions and could be targeted to slow the aging process. One commonly used marker to examine senescent cells in vivo is p16, which has led to important discoveries. Recent studies have also described new senescence markers beyond p16 and have highlighted the importance of investigating senescence heterogeneity in cell types and tissues. With the development of high-throughput technologies, such as single-cell RNA-seq and single-nucleus RNA-seq, we can examine senescent cells at the single-cell level and potentially uncover new markers. This review emphasizes that there is an urgent need to investigate senescence heterogeneity and discuss how this could be accomplished by using advanced technologies and sequencing datasets.

引用

页码：9 / 17

页数：9

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