Cholinesterase activity as a potential biomarker for neurotoxicity induced by pesticides in vivo exposed Oreochromis niloticus (Nile tilapia): assessment tool for organophosphates and synthetic pyrethroids

被引：8

作者：

Amin, Muhammad ^{[1
]}

Yousuf, Masarrat ^{[1
]}

Attaullah, Mohammad ^{[2
]}

Ahmad, Naveed ^{[3
]}

Azra, Mohamad Nor ^{[4
]}

Lateef, Mehreen ^{[5
]}

Buneri, Islam Dad ^{[1
]}

Zekker, Ivar ^{[6
]}

Batiha, Gaber El-Saber ^{[7
]}

Aboelenin, Salma Mostafa ^{[8
]}

Zahoor, Muhammad ^{[9
]}

Ikram, Muhammad ^{[10
]}

Naeem, Muhammad ^{[10
]}

机构：

[1] Univ Karachi, Dept Zool, Karachi 75260, Pakistan

[2] Univ Malakand, Dept Zool, Chakdara, Pakistan

[3] Bahria Univ, Dept Maritime Sci, Karachi, Pakistan

[4] Univ Malaysia Terengganu, Inst Trop Aquaculture & Fisheries, Terengganu, Malaysia

[5] Bahria Univ Med & Dent Coll, Biochem Dept, Karachi, Pakistan

[6] Univ Tartu, Inst Chem, Ravila 14a, Tartu, Estonia

[7] Damanhour Univ, Fac Vet Med, Dept Pharmacol & Therapeut, Damanhour, Egypt

[8] Taif Univ, Turabah Univ Coll, Biol Dept, At Taif, Saudi Arabia

[9] Univ Malakand, Dept Biochem, Khyber Pakhtunkhwa, Pakistan

[10] Abdul Wali Khan Univ, Dept Chem, Mardan, Pakistan

来源：

ENVIRONMENTAL TECHNOLOGY | 2023年 / 44卷 / 14期

关键词：

Pesticides; sub-lethal toxicity; acetylcholinesterase activity; Oreochromis niloticus; organophosphates; FRESH-WATER FISH; ACUTE TOXICITY; ACETYLCHOLINESTERASE ACTIVITY; LIPID-PEROXIDATION; RAINBOW-TROUT; MALATHION; BEHAVIOR; PROTEIN; ACHE; CHLORPYRIFOS;

D O I：

10.1080/09593330.2021.2024276

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Organophosphates (OPs) and synthetic pyrethroids (SPs) are the most popular broad spectrum pesticides, used in agriculture as they have a strong pesticidal activity while also being biodegradable in the environment. The present study aimed to demonstrate the effects of these pesticides on the Acetylcholinesterase (AChE) activity in brain, gills and body muscles of Oreochromis niloticus - an important enzyme for the assessment and biomonitoring pollution caused by neurotoxins in the environment. The fish were exposed for 24 and 48 h to the LC0 concentrations of the malathion (1.425 mg/L), the chlorpyrifos (0.125 mg/L) and the lambda-cyhalothrin (0.0039 mg/L), respectively. The activity of the AChE was significantly increased (p < 0.05) at 24 h and decreased at 48 h (except for the chlorpyrifos-treated brain and gills while tissues had shown no activity at 48 h's exposure) in all pesticides-treated tissues. The maximum increase in the activity and inhibition in the AChE activity were recorded as +92% and -52% in the chlorpyrifos and the lambda-cyhalothrin exposed brain tissues, respectively. Thus, the alterations in the AChE activities indicated that the applied pesticides are highly neurotoxic to fish and the enzyme (AChE) could be used as a useful biomarker for estimation of water pollution.

引用

页码：2148 / 2156

页数：9

共 54 条

[51] Toxic Effects of Endosulfan on Behaviour, Protein Contents and Antioxidant Enzyme System in Gills, Brain, Liver and Muscle Tissues of Rohu, Labeo rohita [J].