How far are we from reliable metabolomics-based biomarkers? The often-overlooked importance of addressing inter-individual variability factors

被引：6

作者：

Gonzalez-Dominguez, Alvaro ^{[1
]}

Gonzalez-Dominguez, Raul ^{[1
]}

机构：

[1] Univ Cadiz, Hosp Univ Puerta del Mar, Inst Invest & Innovac Biomed Cadiz INiBICA, Cadiz 11009, Spain

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2024年 / 1870卷 / 01期

关键词：

Metabolomics; Biomarkers; Inter-individual variability; Validation; Alzheimer's disease; APP/PS1 TRANSGENIC MODEL; ALZHEIMERS-DISEASE; MASS-SPECTROMETRY; SERUM; IDENTIFICATION; ELUCIDATION; PROGRESSION; PATHWAYS; BRAIN; MICE;

D O I：

10.1016/j.bbadis.2023.166910

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metabolomics has proven great potential to unravel the molecular basis of diseases. However, most attempts aimed at identifying reliable metabolomics-based biomarkers for diagnosis, prediction, and prognosis of diseases have repeatedly failed because of inconsistent results and unsatisfactory replication in independent cohorts. This review article explores the possible causes behind this reproducibility crisis, with special focus on the role that inter-individual variability factors play in modulating the susceptibility to disease development. Furthermore, we provide future perspectives on the applicability of metabolomics in biomedical research and its translatability into clinical practice.

引用

页数：6