Whey Protein Supplementation with or without Vitamin D on Sarcopenia-Related Measures: A Systematic Review and Meta-Analysis

被引：41

作者：

Nasimi, Nasrin ^{[1
,2
]}

Sohrabi, Zahra ^{[1
,2
]}

Nunes, Everson A. ^{[3
,4
]}

Sadeghi, Erfan ^{[5
]}

Jamshidi, Sanaz ^{[6
]}

Gholami, Zohreh ^{[1
]}

Akbarzadeh, Marzieh ^{[1
,2
]}

Faghih, Shiva ^{[1
,2
]}

Akhlaghi, Masoumeh ^{[1
,2
]}

Phillips, Stuart M. ^{[3
]}

机构：

[1] Shiraz Univ Med Sci, Sch Nutr &Food Sci, Dept Community Nutr, Shiraz, Iran

[2] Shiraz Univ Med Sci, Nutr Res Ctr, Sch Nutr & Food Sci, Shiraz, Iran

[3] McMaster Univ, Dept Kinesiol, Exercise Metab Res Grp, Hamilton, ON, Canada

[4] Univ Fed Santa Catarina, Dept Physiol Sci, Lab Invest Chron Dis, Florianopolis, Brazil

[5] Shiraz Univ Med Sci, Res Consultat Ctr RCC, Shiraz, Iran

[6] Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran

来源：

ADVANCES IN NUTRITION | 2023年 / 14卷 / 04期

基金：

加拿大自然科学与工程研究理事会; 加拿大健康研究院;

关键词：

resistance exercise; frailty; muscle; mobility; physical function; FAT-FREE MASS; DOUBLE-BLIND; OLDER-ADULTS; MUSCLE MASS; PHYSICAL PERFORMANCE; RESISTANCE EXERCISE; BODY-COMPOSITION; ELDERLY-PEOPLE; LEAN MASS; STRENGTH;

D O I：

10.1016/j.advnut.2023.05.011

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The effects of supplementation with whey protein alone or with vitamin D on sarcopenia-related outcomes in older adults are unclear. We aimed to assess the effect of whey protein supplementation alone or with vitamin D on lean mass (LM), strength, and function in older adults with or without sarcopenia or frailty. We searched PubMed, Web of Science, and SCOPUS databases. Randomized controlled trials (RCT) that investigated the effect of whey protein supplementation with or without vitamin D on sarcopenia outcomes in healthy and sarcopenic or frail older adults were included. Standardized mean differences (SMDs) were calculated for LM, muscle strength, and physical function data. The analysis showed that whey protein supplementation had no effect on LM and muscle strength; nevertheless, a significant improvement was found in physical function (SMD = 0.561; 95% confidence interval [CIs]: 0.256, 0.865, n = 33), particularly gait speed (GS). On the contrary, whey protein supplementation significantly improved LM (SMD = 0.982; 95% CI: 0.228, 1.736; n = 11), appendicular lean mass and physical function (SMD = 1.211; 95% CI: 0.588, 1.834; n = 16), and GS in sarcopenic/frail older adults. By contrast, co-supplementation with vitamin D enhanced LM gains (SMD =0.993; 95% CI: 0.112, 1.874; n = 11), muscle strength (SMD =2.005; 95% CI: 0.975, 3.035; n = 11), and physical function (SMD = 3.038; 95% CI: 2.196, 3.879; n = 18) significantly. Muscle strength and physical function improvements after whey protein supplementation plus vitamin D were observed without resistance exercise (RE) and short study duration subgroups. Moreover, the combination of whey protein and vitamin D with RE did not enhance the effect of RE. Whey protein supplementation improved LM and function in sarcopenic/frail older adults but had no positive effect in healthy older persons. By contrast, our meta-analysis showed that co-supplementation with whey protein and vitamin D is effective, particularly in healthy older adults, which is likely owing, we propose, to the correction of vitamin D insufficiency or deficiency.The trial was registered at https://inplasy.com as INPLASY202240167.

引用

页码：762 / 773

页数：12

共 75 条

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