HBM4EU feasibility studies: Lessons learned in combining health and human biomonitoring studies

被引:0
|
作者
Elonheimo, Hanna Maria [1 ]
Uusitalo, Karoliina [1 ,2 ]
Moore, Sonja [1 ,3 ]
Andersson, Anna-Maria [4 ,5 ]
Baber, Ronny [6 ,7 ]
Wirkner, Kerstin [8 ,9 ]
David, Madlen [10 ]
Kolossa-Gehring, Marike [10 ]
Stewart, Lorraine [11 ]
Sepai, Ovnair [11 ]
Lermen, Dominik [12 ]
Bartel-Steinbach, Martina [12 ]
Rantakokko, Panu [13 ]
Koponen, Jani [13 ]
Tolonen, Hanna [1 ]
机构
[1] Finnish Inst Hlth & Welf THL, Dept Publ Hlth & Welf, Mannerheimintie 166, Helsinki 00271, Finland
[2] Univ Jyvaskyla JYU, Fac Sport & Hlth Sci, Jyvaskyla, Finland
[3] Univ Eastern Finland UEF, Inst Publ Hlth & Clin Nutr, Kuopio Campus, Kuopio, Finland
[4] Rigshospitalet, Dept Growth & Reprod, Copenhagen, Denmark
[5] Rigshospitalet, Int Ctr Res & Res Training Endocrine Disrupt Male, Copenhagen, Denmark
[6] Univ Leipzig, Med Ctr, Inst Lab Med, Clin Chem & Mol Diagnost, Leipzig, Germany
[7] Univ Leipzig, Leipzig Med Biobank, Leipzig, Germany
[8] Univ Leipzig, Leipzig Res Ctr Civilizat Dis, LIFE, Leipzig, Germany
[9] Univ Leipzig, Inst Med Informat Stat & Epidemiol, Leipzig, Germany
[10] German Environm Agcy UBA, Berlin, Germany
[11] UK Hlth Secur Agcy Radiat Chem & Environm Hazards, Harwell Campus, Chilton, Oxon, England
[12] Fraunhofer Inst Biomed Engn IBMT, Sulzbach, Germany
[13] Finnish Inst Hlth & Welf THL, Dept Hlth Secur, Neulaniementie 4, Kuopio 70210, Finland
基金
欧盟地平线“2020”;
关键词
HBM4EU; Human biomonitoring (HBM); Health examination surveys (HESs); Feasibility studies; Environmental chemicals; Environmental health; DESIGN; RATES;
D O I
10.1016/j.ijheh.2022.114100
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background: The European Human Biomonitoring Initiative (HBM4EU) is a joint program evaluating humans' exposure to several environmental substances and their potential health effects. One of the main objectives of HBM4EU is to make use of human biomonitoring (HBM) to assess human exposure to chemicals in Europe to better understand the associated health impacts and to improve chemical risk assessment. In parallel to HBM studies, health examination surveys (HESs), nutrition/dietary surveys, and disease specific health surveys are conducted in many European countries. In HESs, information collected by questionnaire(s) is supplemented with physical examinations and analysis of clinical and biological biomarkers in biological samples. HBM and health examination survey (HES) use similar data collection methods and infrastructures hence the feasibility of combining these two is explored in this paper. Methods: Within HBM4EU, three feasibility studies (in Finland, Germany, and UK/England) were conducted to evaluate opportunities and obstacles of combining HBM and health studies. In this paper we report lessons learned from these feasibility studies. Results: The Finnish feasibility study called KouBio-KUOPIO study was a new initiative without links to existing studies. The German feasibility study added a HBM module to the first follow-up examination of the LIFE-Adult -Study, a population-based cohort study. The UK feasibility integrates a sustainable HBM module into the Health Survey for England (HSfE), an annual health examination survey. Benefits of combining HBM and HESs include the use of shared infrastructures. Furthermore, participants can receive additional health information from HES, and participation rates tend to be higher due to the potential to obtain personal health information. Preparatory phases including obtaining ethical approval can be time-consuming and complicated. Recruitment of participants and low participation rates are common concerns in survey research and therefore designing user-friendly questionnaires with low participant burden is important. Unexpected events such as the COVID-19 pandemic can cause substantial challenges and delays for such studies. Furthermore, experiences from several countries demonstrated that long-term funding for combined studies can be difficult to obtain. Conclusions: In the future, incorporating HBM modules into existing HESs can provide a feasible and cost-effective method to conduct HBM studies and obtain a wide range of relevant data to support public health policies and research
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页数:8
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