Two new β-carboline alkaloids from the roots of Anemone altaica

被引：0

作者：

Du, Kun ^{[1
,2
]}

Zeng, Meng-Nan ^{[1
]}

Wang, Yan-Zhi ^{[1
,2
]}

Liu, Yu-Fei ^{[1
]}

Feng, Wei-Sheng ^{[2
]}

机构：

[1] Henan Univ Chinese Med, Sch Pharm, Zhengzhou 450046, Peoples R China

[2] Collaborat Innovat Ctr Chinese Med & Resp Dis Coco, Zhengzhou 450046, Peoples R China

来源：

JOURNAL OF NATURAL MEDICINES | 2023年 / 77卷 / 02期

关键词：

Ranunculaceae; Anemone altaica; beta-carboline alkaloid; Anemonilins A and B;

D O I：

10.1007/s11418-023-01679-w

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new beta-carboline alkaloids, anemonilins A and B (1-2), and two known beta-carboline alkaloids, flazine (3) and 4-(9H-beta-carbolin-l-yl)-4-oxo-butyric acid (4), were isolated from the roots of Anemone altaica. The structures of the isolated compounds were elucidated with spectroscopic and spectrometric methods (1D and 2DNMR, HRESIMS). Compounds 2 and 4 significantly attenuated the growth inhibition induced by lipopolysaccharide (LPS) in normal rat kidney tubule epithelioid (NRK52e) cells (p < 0.05 or p < 0.01). Furthermore, compound 2 significantly reduced the apoptosis (p < 0.05) and the caspase-3/9 expression of NRK52e cells induced by LPS. [GRAPHICS] .

引用

页码：397 / 402

页数：6

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