Carrier protein mediated cargo sensing in quorum signal synthases

被引：2

作者：

Fischer, Patrick D. ^{[1
,3
,4
]}

Chowdhury, Abu Sayeed ^{[6
]}

Bartholow, Thomas ^{[5
]}

Basu, Shibani ^{[2
]}

Baggs, Eric ^{[2
]}

Cox, Huel S. ^{[1
,3
]}

Matosin, Srdan ^{[1
,3
]}

Burkart, Michael D. ^{[5
]}

Warner, Lisa ^{[2
]}

Nagarajan, Rajesh ^{[2
]}

Arthanari, Haribabu ^{[1
,3
]}

机构：

[1] Harvard Med Sch, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[2] Boise State Univ, Dept Chem & Biochem, Boise, ID 83725 USA

[3] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA

[4] Saarland Univ, Dept Pharm Pharmaceut & Med Chem, Saarbrucken, Germany

[5] Univ Calif San Diego,, Dept Chem & Biochem, San Diego, CA USA

[6] Boise State Univ, Biomol Sci Grad Program, Boise, ID USA

来源：

CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 08期

关键词：

Bacteria; -; Proteins;

D O I：

10.1039/d2cc03551k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Acyl-homoserine lactone synthases make specific AHL quorum sensing signals to aid virulence in Gram-negative bacteria. Here, we use solution NMR spectroscopy to demonstrate that the carrier protein-enzyme interface accurately reveals substrate recognition mechanisms in two quorum signal synthases.

引用

页码：1014 / 1017

页数：4

共 18 条

[1] Structure of the enzyme-acyl carrier protein (ACP) substrate gatekeeper complex required for biotin synthesis
Agarwal, Vinayak
Lin, Steven
Lukk, Tiit
Nair, Satish K.
Cronan, John E.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (43) : 17406 - 17411
[2] Aurelien, 2009, MOL MICROBIOL, V74, P903
[3] The Burkholderia mallei BmaR3-BmaI3 quorum-sensing system produces and responds to N-3-hydroxy-octanoyl homoserine lactone
Duerkop, Breck A.
Herman, Jake P.
Ulrich, Ricky L.
Churchill, Mair E. A.
Greenberg, E. Peter
[J]. JOURNAL OF BACTERIOLOGY, 2008, 190 (14) : 5137 - 5141
[4] Octanoyl-homoserine lactone is the cognate signal for Burkholderia mallei BmaR1-BmaI1 quorum sensing
Duerkop, Breck A.
Ulrich, Ricky L.
Greenberg, E. Peter
[J]. JOURNAL OF BACTERIOLOGY, 2007, 189 (14) : 5034 - 5040
[5] Quorum-Sensing Control of Antibiotic Synthesis in Burkholderia thailandensis
Duerkop, Breck A.
Varga, John
Chandler, Josephine R.
Peterson, Snow Brook
Herman, Jake P.
Churchill, Mair E. A.
Parsek, Matthew R.
Nierman, William C.
Greenberg, E. Peter
[J]. JOURNAL OF BACTERIOLOGY, 2009, 191 (12) : 3909 - 3918
[6] Specificity of acyl-homoserine lactone synthases examined by mass spectrometry
Gould, TA
Herman, J
Krank, J
Murphy, RC
Churchill, MEA
[J]. JOURNAL OF BACTERIOLOGY, 2006, 188 (02) : 773 - 783
[7] Quorum sensing controls biofilm formation in Vibrio cholerae
Hammer, BK
Bassler, BL
[J]. MOLECULAR MICROBIOLOGY, 2003, 50 (01) : 101 - 114
[8] Quorum-sensing regulation governs bacterial adhesion, biofilm development, and host colonization in Pantoea stewartii subspecies stewartii
Koutsoudis, MD
Tsaltas, D
Minogue, TD
von Bodman, SB
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (15) : 5983 - 5988
[9] Insights into -ketoacyl-chain recognition for -ketoacyl-ACP utilizing AHL synthases
Lam, Mila Nhu
Dudekula, Dastagiri
Durham, Bri
Collingwood, Noah
Brown, Eric C.
Nagarajan, Rajesh
[J]. CHEMICAL COMMUNICATIONS, 2018, 54 (64) : 8838 - 8841
[10] Acyl-phosphates initiate membrane phospholipid synthesis in gram-positive pathogens
Lu, Ying-Jie
Zhang, Yong-Mei
Grimes, Kimberly D.
Qi, Jianjun
Lee, Richard E.
Rock, Charles O.
[J]. MOLECULAR CELL, 2006, 23 (05) : 765 - 772

← 1 2 →