Nanoparticle-based nontransformative RNA insecticides for sustainable pest control: mechanisms, current status and challenges

被引：58
作者：
Yan, Shuo [1 ,2 ]
Yin, Mei-Zhen [3 ]
Shen, Jie [1 ,2 ]
机构：
[1] China Agr Univ, Dept Plant Biosecur, Beijing 100193, Peoples R China
[2] China Agr Univ, Coll Plant Protect, MARA Key Lab Surveillance & Management Plant Quara, Beijing 100193, Peoples R China
[3] Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing Lab Biomed Mat, Beijing 100029, Peoples R China
来源：
ENTOMOLOGIA GENERALIS | 2023年 / 43卷 / 01期
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
dsRNA delivery; Nanocarrier; Pest management; RNAi efficiency; RNA pesticide; DOUBLE-STRANDED-RNA; CROP PROTECTION; NEXT-GENERATION; AEDES-AEGYPTI; DSRNA; GENE; DELIVERY; INTERFERENCE; DNA; ENDOCYTOSIS;
D O I：
10.1127/entomologia/2022/1618
中图分类号：
Q96 [昆虫学];
学科分类号：
摘要：
RNA interference (RNAi) described as post transcriptional gene silencing offers great opportunities for developing RNA insecticide for sustainable pest management. In the past decade, nano-delivery system has been widely applied to deliver double-stranded RNA (dsRNA), which shows great potential in improving the stability and delivery efficiency of dsRNA for efficient RNAi both in vitro and in vivo. Here, we introduce the current limiting factors of successful RNAi in insect pests and the advantages of nano-delivery system, reveal the process and mechanism of nanocarrier-mediated RNAi, summarize the successful applications of nanocarrier-based RNA insecticide, and finally propose the current challenges and future perspective.
引用
收藏
页码：21 / 30
页数：10
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