Akkermansia muciniphila plays critical roles in host health

被引：57
作者：
Zhao, Qixiang [1 ,2 ,3 ]
Yu, Jiadong [1 ,2 ,3 ]
Hao, Yan [1 ,2 ,3 ]
Zhou, Hong [1 ,2 ,3 ]
Hu, Yawen [1 ,2 ,3 ]
Zhang, Chen [1 ,2 ,3 ]
Zheng, Huaping [1 ,2 ,3 ]
Wang, Xiaoyan [1 ,2 ,3 ]
Zeng, Fanlian [1 ,2 ,3 ]
Hu, Jing [1 ,2 ,3 ]
Gu, Linna [1 ,2 ,3 ]
Wang, Zhen [1 ,2 ,3 ]
Zhao, Fulei [1 ,2 ,3 ]
Yue, Chengcheng [1 ,2 ,3 ]
Zhou, Pei [1 ,2 ,3 ]
Zhang, Haozhou [1 ,2 ,3 ]
Huang, Nongyu [1 ,2 ,3 ]
Wu, Wenling [1 ,2 ,3 ]
Zhou, Yifan [1 ,2 ,3 ]
Li, Jiong [1 ,2 ,3 ]
机构：
[1] Sichuan Univ, West China Hosp, West China Med Sch, State Key Lab Biotherapy, Chengdu, Peoples R China
[2] Sichuan Univ, West China Hosp, Canc Ctr, West China Med Sch, Chengdu, Peoples R China
[3] Collaborat Innovat Ctr Biotherapy, Chengdu, Peoples R China
来源：
CRITICAL REVIEWS IN MICROBIOLOGY | 2023年 / 49卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Akkermansia muciniphila; mucin; intestinal barrier; immune function; intestinal microbiota; ENDOTOXEMIA-INDUCED INFLAMMATION; GUT MICROBIOTA; INTESTINAL MICROBIOME; MEMBRANE-VESICLES; BODY-WEIGHT; MUCIN; PROTEIN; MICE; DIVERSITY; BACTERIA;
D O I：
10.1080/1040841X.2022.2037506
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Akkermansia muciniphila, an intestinal microorganism, belongs to Verrucomicrobia, one of the most abundant microorganisms in the mammalian gut. It is a mucin-degrading bacterium that can colonise intestines of mammals such as humans and mice by utilising mucin as the only nitrogen and carbon source. When A. muciniphila colonises the intestine, its metabolites interact with the intestinal barrier, affecting host health by consolidating the intestinal barrier, regulating metabolic functions of the intestinal and circulatory systems, and regulating immune functions. This review summarised the mechanisms of A. muciniphila-host interactions that are relevant to host health. We focussed on characteristics of A. muciniphila in relation to its metabolites to provide a comprehensive understanding of A. muciniphila and its effects on host health and disease processes.
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页码：82 / 100
页数：19
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