Mortality predictors in patients with native valve infective endocarditis

Introduction: Mortality of infective endocarditis (IE) in Argentina continues to be high. The aim objective was to describe the clinical characteristics and identify factors associated with in -hospital and long-term mortality in patients with native valve IE. Methods: Retrospective cohort study including adult patients with diagnosis of native valve IE, hospitalized during 2011-2021. Results: A total of 129 patients with a mean age of 66 +/- 17 years were included. The most frequent responsible organism was Staphylococcus aureus (SA) (3 8.8%). Surgical indication criteria were present in 63.6% of the patients. Mortality during hospitalization was 22.5% .In the multivariate analysis that included Charlson comorbidity index, SA infection and the presence of surgical indication criteria, an adjusted OR of mortality of 1.32 (95% CI 1.10-1.57 ; p = 0.003), 2.75 (95%CI 1.11-6.8; p = 0.028) and 4.14 (95%CI 1.34-12; p = 0.013), respectively, was observed. In the multivariate analysis for long term mortality, that added surgical indication criteria and the performance of surgery during hospitalization, an adjusted OR of 1.62 (CI95% 1.31-2.00; p<001), 0.77 (95%CI 0.31-1.93; p = 0.58), 7.49 (95%CI 2.07-27.07; p = 0.002) and 0.21 (95%CI 0.06-0.70; p = 0.01), respectively, was observed. Conclusions: Mortality in IE was associated with the degree of previous comorbidity, with the presence of surgical indication criteria and, inversely, with the timely completion of surgical treatment.