Peanut-natto improved obesity of high-fat diet mice by regulating gut microbiota and lipid metabolism

被引:11
|
作者
Cao, Shufang [1 ]
Yang, Lina [1 ,2 ]
Xie, Mengxi [2 ]
Yu, Miao [2 ]
Shi, Taiyuan [2 ]
机构
[1] Bohai Univ, Coll Food Sci & Engn, Jinzhou 121013, Liaoning, Peoples R China
[2] Liaoning Acad Agr Sci, Food & Proc Res Inst, Shenyang 110161, Liaoning, Peoples R China
关键词
Peanut-natto; Obesity mice; Gut microbiota; Lipid metabolism; PREVENTS OBESITY; INFLAMMATION; ACID;
D O I
10.1016/j.jff.2023.105956
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Globally, the incidence of diseases such as obesity, fatty liver and hyperlipidaemia has increased drastically in recent years. This study investigated the direct treatment of obesity and its associated metabolic disorders using peanut-natto in a high-fat diet (HFD)-induced mouse model of obesity. After 6 weeks of treatment, peanut-natto significantly reduced the body and abdominal fat weight of mice with obesity, decreased the fat cell area and fat droplet accumulation in the liver and improved the colon structure by regulating the levels of intestinal lipid metabolism-related proteins such as CD36 and FATP4. Compared with the untreated HFD group, peanut-natto significantly reduced the serum levels of LDL-C, TG and T-CHO. Metagenomic analysis revealed that natto can restore the abundance of gut microbiota to a certain extent and increase the Bacteroidetes-to-Firmicutes ratio. Non-targeted metabolomics analysis indicated a metabolism disorder that was obviously improved by peanut-natto treatment via the regulation of alpha-linolenic acid metabolism, linoleic acid metabolism, unsaturated fatty acid biosynthesis and lipid decomposition in fat cells. These results provide a scientific basis for using peanut-natto as a new food product to prevent obesity, improve metabolic disorders and balance the intestinal microbiota.
引用
收藏
页数:11
相关论文
empty
未找到相关数据