Post-COVID-19 Condition in Children 6 and 12 Months After Infection

被引：3

作者：

Dun-Dery, Frederick ^{[1
]}

Xie, Jianling ^{[2
]}

Winston, Kathleen ^{[1
]}

Burstein, Brett ^{[3
,4
]}

Gravel, Jocelyn ^{[5
]}

Emsley, Jason ^{[6
,7
]}

Sabhaney, Vikram ^{[8
,9
]}

Zemek, Roger ^{[10
,11
]}

Berthelot, Simon ^{[12
]}

Beer, Darcy ^{[13
]}

Kam, April ^{[14
]}

Freire, Gabrielle ^{[15
]}

Mater, Ahmed ^{[16
]}

Porter, Robert ^{[17
]}

Poonai, Naveen ^{[18
,19
,20
]}

Moffatt, Anne ^{[21
]}

Dixon, Andrew ^{[22
]}

Salvadori, Marina I. ^{[23
,24
]}

Freedman, Stephen B. ^{[25
,26
,27
,28
]}

机构：

[1] Univ Calgary, Cumming Sch Med, Dept Pediat, Calgary, AB, Canada

[2] Univ Calgary, Cumming Sch Med, Dept Pediat, Sect Pediat Emergency Med, Calgary, AB, Canada

[3] McGill Univ Hlth Ctr, Div Pediat Emergency Med, Dept Pediat, Montreal Childrens Hosp, Montreal, PQ, Canada

[4] McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada

[5] Univ Montreal, Ctr Hosp Univ CHU St Justine, Dept Psychiat & Neurosci, Montreal, PQ, Canada

[6] Dalhousie Univ, IWK Childrens Hlth Ctr, Dept Emergency Med, Halifax, NS, Canada

[7] Dalhousie Univ, Queen Elizabeth II Hlth Sci Ctr, Halifax, NS, Canada

[8] Univ British Columbia, Dept Paediat, BC Childrens Hosp, Vancouver, BC, Canada

[9] Univ British Columbia, Dept Emergency Med, BC Childrens Hosp, Vancouver, BC, Canada

[10] Univ Ottawa, Childrens Hosp Eastern Ontario, Dept Pediat, Ottawa, ON, Canada

[11] Univ Ottawa, Childrens Hosp Eastern Ontario, Dept Emergency Med, Ottawa, ON, Canada

[12] Univ Laval, CHU Quebec, Dept Med Famille & Med Urgence, Quebec City, PQ, Canada

[13] Univ Manitoba, Childrens Hosp Winnipeg, Childrens Hosp Res Inst Manitoba, Dept Pediat & Child Hlth, Winnipeg, MB, Canada

[14] McMaster Childrens Hosp, Dept Pediat, Div Emergency Med, Hamilton, ON, Canada

[15] Univ Toronto, Hosp Sick Children, Div Emergency Med, Dept Paediat,Fac Med, Toronto, ON, Canada

[16] Univ Saskatchewan, Jim Pattison Childrens Hosp, Dept Pediat, Sect Pediat Emergency, Saskatoon, SK, Canada

[17] Newfoundland & Labrador Hlth Serv, Janeway Childrens Hlth & Rehabil Ctr, St John, NF, Canada

[18] Childrens Hosp, London Hlth Sci Ctr, Schulich Sch Med & Dent, Dept Paediat, London, ON, Canada

[19] Schulich Sch Med & Dent, Dept Internal Med, London, ON, Canada

[20] Schulich Sch Med & Dent, Dept Epidemiol & Biostat, London, ON, Canada

[21] Queens Univ, Kingston Hlth Sci Ctr, Dept Radiol, Kingston, ON, Canada

[22] Univ Alberta, Sect Pediat Emergency Med, Dept Pediat Womens & Childrens Hlth Res Inst, Edmonton, AB, Canada

[23] Publ Hlth Agcy Canada, Ottawa, ON, Canada

[24] McGill Univ, Dept Pediat, Montreal, PQ, Canada

[25] Univ Calgary, Cumming Sch Med, Dept Pediat, Sect Pediat Emergency Med, Calgary, AB, Canada

[26] Univ Calgary, Cumming Sch Med, Dept Pediat, Gastroenterol Sect, Calgary, AB, Canada

[27] Univ Calgary, Cumming Sch Med, Dept Emergency Med, Sect Pediat Emergency Med, Calgary, AB, Canada

[28] Univ Calgary, Cumming Sch Med, Dept Emergency Med, Gastroenterol Sect, Calgary, AB, Canada

来源：

JAMA NETWORK OPEN | 2023年 / 6卷 / 12期

基金：

加拿大健康研究院;

关键词：

PEDSQL(TM)-4.0; RELIABILITY; RISK;

D O I：

10.1001/jamanetworkopen.2023.49613

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Importance There is a need to understand the long-term outcomes among children infected with SARS-CoV-2.Objective To quantify the prevalence of post-COVID-19 condition (PCC) among children tested for SARS-CoV-2 infection in pediatric emergency departments (EDs).Design, Setting, and Participants Multicenter, prospective cohort study at 14 Canadian tertiary pediatric EDs that are members of the Pediatric Emergency Research Canada network with 90-day, 6-month, and 12-month follow-up. Participants were children younger than 18 years who were tested for SARS-CoV-2 infection between August 2020 and February 2022. Data were analyzed from May to November 2023.Exposure The presence of SARS-CoV-2 infection at or within 14 days of the index ED visit.Main Outcomes and Measures Presence of symptoms and QoL reductions that meet the PCC definition. This includes any symptom with onset within 3 months of infection that is ongoing at the time of follow-up and affects everyday functioning. The outcome was quantified at 6 and 12 months following the index ED visit.Results Among the 5147 children at 6 months (1152 with SARS-CoV-2 positive tests and 3995 with negative tests) and 5563 children at 12 months (1192 with SARS-CoV-2 positive tests and 4371 with negative tests) who had sufficient data regarding the primary outcome to enable PCC classification, the median (IQR) age was 2.0 (0.9-5.0) years, and 2956 of 5563 (53.1%) were male. At 6-month follow-up, symptoms and QoL changes consistent with the PCC definition were present in 6 of 1152 children with positive SARS-CoV-2 tests (0.52%) and 4 of 3995 children with negative SARS-CoV-2 tests (0.10%; absolute risk difference, 0.42%; 95% CI, 0.02% to 0.94%). The PCC definition was met at 12 months by 8 of 1192 children with positive SARS-CoV-2 tests (0.67%) and 7 of 4371 children with negative SARS-CoV-2 tests (0.16%; absolute risk difference, 0.51%; 95% CI, 0.06 to 1.08%). At 12 months, the median (IQR) PedsQL Generic Core Scale scores were 98.4 (90.0-100) among children with positive SARS-CoV-2 tests and 98.8 (91.7-100) among children with negative SARS-CoV-2 tests (difference, -0.3; 95% CI, -1.5 to 0.8; P = .56). Among the 8 children with SARS-CoV-2 positive tests and PCC at 12-month follow-up, children reported respiratory (7 of 8 patients [88%]), systemic (3 of 8 patients [38%]), and neurologic (1 of 8 patients [13%]) symptoms.Conclusions and Relevance In this cohort study of children tested for SARS-CoV-2 infection in Canadian pediatric EDs, although children infected with SARS-CoV-2 reported increased chronic symptoms, few of these children developed PCC, and overall QoL did not differ from children with negative SARS-CoV-2 tests.

引用

页数：13

共 38 条

[1] Simple and effective confidence intervals for proportions and differences of proportions result from adding two successes and two failures
Agresti, A
Caffo, B
[J]. AMERICAN STATISTICIAN, 2000, 54 (04) : 280 - 288
[2] [Anonymous], 2022, Nearly one in five American adults who have had COVID-19 still have "Long COVID
[3] Risk of long COVID associated with delta versus omicron variants of SARS-CoV-2
Antonelli, Michela
Pujol, Joan Capdevila
Spector, Tim D.
Ourselin, Sebastien
Steves, Claire J.
[J]. LANCET, 2022, 399 (10343) : 2263 - 2264
[4] CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING
BENJAMINI, Y
HOCHBERG, Y
[J]. JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1995, 57 (01) : 289 - 300
[5] The relationship between Post COVID symptoms in young people and their parents
Bertran, Marta
Pereira, Snehal M. Pinto
Nugawela, Manjula D.
Stephenson, Terence
Shafran, Roz
Ford, Tamsin
Buszewicz, Marta
Whittaker, Elizabeth
Heyman, Isobel
Segal, Terry Y.
Dalrymple, Emma
Ladhani, Shamez N.
[J]. JOURNAL OF INFECTION, 2022, 85 (06) : 727 - 729
[6] Pediatric Emergency Research Canada: Origins and Evolution
Bialy, Liza
Plint, Amy
Zemek, Roger
Johnson, David
Klassen, Terry
Osmond, Martin
Freedman, Stephen B.
[J]. PEDIATRIC EMERGENCY CARE, 2018, 34 (02) : 138 - 144
[7] Comparison of mental health outcomes in seropositive and seronegative adolescents during the COVID19 pandemic
Blankenburg, Judith
Wekenborg, Magdalena K.
Reichert, Joerg
Kirsten, Carolin
Kahre, Elisabeth
Haag, Luise
Schumm, Leonie
Czyborra, Paula
Berner, Reinhard
Armann, Jakob P.
[J]. SCIENTIFIC REPORTS, 2022, 12 (01)
[8] Incidence and Characteristics in Children with Post-COVID-19 Condition in Sweden
Bygdell, Maria
Kindblom, Jenny M.
Martikainen, Jari
Li, Huiqi
Nyberg, Fredrik
[J]. JAMA NETWORK OPEN, 2023, 6 (07)
[9] Characterizing long COVID in an international cohort: 7 months of symptoms and their impact
Davis, Hannah E.
Assaf, Gina S.
McCorkell, Lisa
Wei, Hannah
Low, Ryan J.
Re'em, Yochai
Redfield, Signe
Austin, Jared P.
Akrami, Athena
[J]. ECLINICALMEDICINE, 2021, 38
[10] A longitudinal seroepidemiology study to evaluate antibody response to SARS-CoV-2 virus infection and vaccination in children in Calgary, Canada from July 2020 to April 2022: Alberta COVID-19 Childhood Cohort (AB3C) Study
Doucette, Emily J.
Gray, Joslyn
Fonseca, Kevin
Charlton, Carmen
Kanji, Jamil N.
Tipples, Graham
Kuhn, Susan
Dunn, Jessica
Sayers, Payton
Symonds, Nicola
Wu, Guosong
Freedman, Stephen B.
Kellner, James D.
[J]. PLOS ONE, 2023, 18 (04):

← 1 2 3 4 →