Recent progress in miRNA biogenesis and decay

被引：49

作者：

Bofill-De Ros, Xavier ^{[1
,2
]}

Vang Orom, Ulf Andersson ^{[1
]}

机构：

[1] Aarhus Univ, Inst Mol Biol & Genet, RNA Biol & Innovat, Aarhus, Denmark

[2] NCI, RNA Biol Lab, Ctr Canc Res, Frederick, MD USA

来源：

RNA BIOLOGY | 2024年 / 21卷 / 01期

关键词：

miRNA biogenesis; miRNA decay; miRNA stability; miRNA targeting; miRNA therapeutics; MICRORNA DEGRADATION; STRUCTURAL BASIS; RNA; COMPLEX; REVEALS; ENABLES; DICER; PHOSPHORYLATION; DETERMINANTS; RECOGNITION;

D O I：

10.1080/15476286.2023.2288741

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs are a class of small regulatory RNAs that mediate regulation of protein synthesis by recognizing sequence elements in mRNAs. MicroRNAs are processed through a series of steps starting from transcription and primary processing in the nucleus to precursor processing and mature function in the cytoplasm. It is also in the cytoplasm where levels of mature microRNAs can be modulated through decay mechanisms. Here, we review the recent progress in the lifetime of a microRNA at all steps required for maintaining their homoeostasis. The increasing knowledge about microRNA regulation upholds great promise as therapeutic targets.

引用

页码：1 / 8

页数：8

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