Design, synthesis and insilico studies of 3-fluoro-3-substituted oxindoles against cancer targets

Isatin and substituted isatins were subjected to Aldol condensation with various ketones. The resulted 3-hydroxy compounds were transformed into fluorine derivatives. Thus obtained, 3-fluoro-3-substituted oxindoles were screened for Insilco evaluation against anti-cancer targets VEGFR2 and GSK-3 beta. The study reveals that the fluoro compounds showed binding at their active sites. Particularly, compounds 4i, 4n and 4q shows the best binding affinity and similar hydrophobic interactions as their respective co-crystallized ligands.