Development and Validation of a Prognostic Risk Model Based on Nature Killer Cells for Serous Ovarian Cancer

被引:2
作者
Zhang, Chengxi [1 ,2 ]
Qin, Chuanmei [1 ,2 ]
Lin, Yi [3 ]
机构
[1] Shanghai Jiao Tong Univ, Int Peace Matern & Child Hlth Hosp, Sch Med, Shanghai 200030, Peoples R China
[2] Shanghai Key Lab Embryo Original Dis, Shanghai 200030, Peoples R China
[3] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Reprod Med Ctr, Sch Med, Shanghai 200233, Peoples R China
来源
JOURNAL OF PERSONALIZED MEDICINE | 2023年 / 13卷 / 03期
关键词
ovarian cancer; nature killer (NK) cell; tumor microenvironment; single-cell RNA-sequencing; prognostic risk model; immunotherapy; MESSENGER-RNA-SEQ; T-CELLS; SURVIVAL; LYMPHOCYTES; ACTIVATION; EXPRESSION; SLC11A1; GROWTH;
D O I
10.3390/jpm13030403
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Nature killer (NK) cells are increasingly considered important in tumor microenvironment, but their role in predicting the prognosis of ovarian cancer has not been revealed. This study aimed to develop a prognostic risk model for ovarian cancer based on NK cells. Firstly, differentially expressed genes (DEGs) of NK cells were found by single-cell RNA-sequencing dataset analysis. Based on six NK-cell DEGs identified by univariable, Lasso and multivariable Cox regression analyses, a prognostic risk model for serous ovarian cancer was developed in the TCGA cohort. This model was then validated in three external cohorts, and evaluated as an independent prognostic factor by multivariable Cox regression analysis together with clinical characteristics. With the investigation of the underlying mechanism, a relation between a higher risk score of this model and more immune activities in tumor microenvironment was revealed. Furthermore, a detailed inspection of infiltrated immunocytes indicated that not only quantity, but also the functional state of these immunocytes might affect prognostic risk. Additionally, the potential of this model to predict immunotherapeutic response was exhibited by evaluating the functional state of cytotoxic T lymphocytes. To conclude, this study introduced a novel prognostic risk model based on NK-cell DEGs, which might provide assistance for the personalized management of serous ovarian cancer patients.
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页数:16
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