Immunocompromised Host Pneumonia: Definitions and Diagnostic Criteria An Official American Thoracic Society Workshop Report

被引：40

作者：

Cheng, Guang-Shing ^{[1
,2
]}

Crothers, Kristina ^{[2
,3
]}

Aliberti, Stefano ^{[5
]}

Bergeron, Anne ^{[6
]}

Boeckh, Michael ^{[1
,2
]}

Chien, Jason W. ^{[7
]}

Cilloniz, Catia ^{[8
,9
]}

Cohen, Keira ^{[10
]}

Dean, Nathan ^{[11
,12
]}

Dela Cruz, Charles S. ^{[13
,14
]}

Dickson, Robert P. ^{[15
]}

Greninger, Alexander L. ^{[16
]}

Hage, Chadi A. ^{[17
]}

Hohl, Tobias M. ^{[18
,19
]}

Holland, Steven M. ^{[20
]}

Jones, Barbara E. ^{[12
,21
]}

Keane, Joseph ^{[22
]}

Metersky, Mark ^{[23
]}

Miller, Rachel ^{[24
]}

Puel, Anne ^{[25
,26
,27
]}

Ramirez, Julio ^{[28
]}

Restrepo, Marcos, I ^{[29
,30
]}

Sheshadri, Ajay ^{[4
]}

Staitieh, Bashar ^{[31
]}

Tarrand, Jeffrey ^{[32
]}

Winthrop, Kevin L. ^{[33
]}

Wunderink, Richard G. ^{[34
]}

Evans, Scott E. ^{[4
]}

机构：

[1] Fred Hutchinson Canc Ctr, Clin Res Div, Seattle, WA USA

[2] Univ Washington, Div Pulm Crit Care & Sleep Med, Dept Med, Seattle, WA USA

[3] Vet Adm Puget Sound Hlth Care Syst, Seattle, WA USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Pulm Med, Houston, TX 70030 USA

[5] Univ Milan, Milan, Italy

[6] Univ Geneva, Pneumol Dept, Geneva, Switzerland

[7] Janssen Pharmaceut, Brisbane, Cambs, England

[8] Univ Barcelona, Barcelona, Spain

[9] Continental Univ, Fac Hlth Sci, Huancayo, Peru

[10] Johns Hopkins Univ, Baltimore, MD USA

[11] Intermt Med Ctr, Murray, KY USA

[12] Univ Utah, Dept Internal Med, Div Pulm & Crit Care Med, Salt Lake City, UT USA

[13] Yale Univ, Dept Internal Med, Sect Pulm Crit Care & Sleep Med, New Haven, CT USA

[14] Vet Affairs Connecticut Healthcare Syst, New Haven, CT USA

[15] Univ Michigan, Med Sch, Ann Arbor, MI USA

[16] Univ Washington, Dept Lab Med & Pathol, Div Virol, Seattle, WA USA

[17] Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, Lung Transplant UPMC, Pittsburgh, PA USA

[18] Mem Sloan Kettering Canc Ctr, Dept Med, Human Oncol & Pathogenesis Program, New York, NY USA

[19] Mem Sloan Kettering Canc Ctr, Immunol Program, New York, NY USA

[20] NIAID, NIH, Bethesda, MD USA

[21] Vet Adm, Salt Lake City, UT USA

[22] Trinity Coll Dublin, Clin Med, St Jamess Hosp, Dublin, Ireland

[23] Univ Connecticut, Sch Med, Farmington, CT USA

[24] Duke Univ, Dept Internal Med, Div Infect Dis, Durham, NC USA

[25] INSERM, Lab Human Genet Infect Dis Paris, Paris, France

[26] Univ Paris Cite, Imagine Inst, Paris, France

[27] Rockefeller Univ, New York, NY USA

[28] Univ Louisville, Div Infect Dis, Louisville, KY USA

[29] South Texas Vet Hlth Care Syst, San Antonio, TX USA

[30] Univ Texas Hlth San Antonio, Dept Med, Div Pulm & Crit Care Med, San Antonio, TX USA

[31] Emory Univ, Dept Med, Div Pulm Allergy Crit Care & Sleep Med, Atlanta, GA USA

[32] Univ Texas MD Anderson Canc Ctr, Dept Lab Med, Houston, TX USA

[33] Oregon Hlth & Sci Univ, Portland, OR USA

[34] Northwestern Univ, Feinberg Sch Med, Dept Med, Pulm & Crit Care Div, Chicago, IL USA

来源：

ANNALS OF THE AMERICAN THORACIC SOCIETY | 2023年 / 20卷 / 03期

关键词：

pneumonia; immunocompromised host; immunosuppression; diagnosis; COMMUNITY-ACQUIRED PNEUMONIA; HEMATOPOIETIC-CELL TRANSPLANTATION; INFECTIOUS-DISEASES SOCIETY; RHEUMATOID-ARTHRITIS; BACTERIAL PNEUMONIA; VIRUS-INFECTION; INBORN-ERRORS; HIV-INFECTION; RISK-FACTORS; TUBERCULOSIS;

D O I：

10.1513/AnnalsATS.202212-1019ST

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Pneumonia imposes a significant clinical burden on people with immunocompromising conditions. Millions of individuals live with compromised immunity because of cytotoxic cancer treatments, biological therapies, organ transplants, inherited and acquired immunodeficiencies, and other immune disorders. Despite broad awareness among clinicians that these patients are at increased risk for developing infectious pneumonia, immunocompromised people are often excluded from pneumonia clinical guidelines and treatment trials. The absence of a widely accepted definition for immunocompromised host pneumonia is a significant knowledge gap that hampers consistent clinical care and research for infectious pneumonia in these vulnerable populations. To address this gap, the American Thoracic Society convened a workshop whose participants had expertise in pulmonary disease, infectious diseases, immunology, genetics, and laboratory medicine, with the goal of defining the entity of immunocompromised host pneumonia and its diagnostic criteria.

引用

页码：341 / 353

页数：13

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