Mechanisms of myeloid leukemogenesis: Current perspectives and therapeutic objectives

被引：23

作者：

Bouligny, Ian M. ^{[1
]}

Maher, Keri R. ^{[1
]}

Grant, Steven ^{[1
]}

机构：

[1] Virginia Commonwealth Univ, Massey Canc Ctr, Richmond, VA 23284 USA

来源：

BLOOD REVIEWS | 2023年 / 57卷

关键词：

Acute myeloid leukemia; Leukemogenesis; Epigenetics; Transcription factor; Oncoprotein; Signal transduction; Cell cycle; Novel strategies; Targeted therapy; CORE-BINDING-FACTOR; HEMATOPOIETIC STEM-CELLS; ACUTE MYELOGENOUS LEUKEMIA; HISTONE DEACETYLASE INHIBITORS; ACUTE LYMPHOBLASTIC-LEUKEMIA; MYELODYSPLASTIC SYNDROMES; DNA METHYLATION; C/EBP-ALPHA; PROGNOSTIC RELEVANCE; GENE-EXPRESSION;

D O I：

10.1016/j.blre.2022.100996

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acute myeloid leukemia (AML) is a heterogeneous hematopoietic neoplasm which results in clonal proliferation of abnormally differentiated hematopoietic cells. In this review, mechanisms contributing to myeloid leukemogenesis are summarized, highlighting aberrations of epigenetics, transcription factors, signal transduction, cell cycling, and the bone marrow microenvironment. The mechanisms contributing to AML are detailed to spotlight recent findings that convey clinical impact. The applications of current and prospective therapeutic targets are accentuated in addition to reviews of treatment paradigms stratified for each characteristic molecular lesion - with a focus on exploring novel treatment approaches and combinations to improve outcomes in AML.

引用

页数：17

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