2-Phenethylamines in Medicinal Chemistry: A Review

被引：25

作者：

Nieto, Carlos T. ^{[1
]}

Manchado, Alejandro ^{[1
]}

Belda, Leland ^{[1
]}

Diez, David ^{[1
]}

Garrido, Narciso M. ^{[1
]}

机构：

[1] Univ Salamanca, Fac Chem Sci, Dept Organ Chem, Pl Caidos s n, Salamanca 37008, Spain

来源：

MOLECULES | 2023年 / 28卷 / 02期

关键词：

2-phenethylamine; medicinal chemistry; ligands; adrenoceptors; carbonyl anhydrase; dopamine receptor; DAT; 5-HT; MAO; PPAR; sigma receptors; TAAR1; ALPHA-SUBSTITUTED PHENETHYLAMINES; PROLIFERATOR-ACTIVATED-RECEPTOR; OBSTRUCTIVE PULMONARY-DISEASE; DIPEPTIDYL-PEPTIDASE-IV; ACTING BETA(2)-ADRENOCEPTOR AGONIST; REVERSE-TRANSCRIPTASE INHIBITORS; ATYPICAL BETA-ADRENOCEPTORS; IN-VITRO; CARBONIC-ANHYDRASE; PHARMACOLOGICAL CHARACTERIZATION;

D O I：

10.3390/molecules28020855

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A concise review covering updated presence and role of 2-phenethylamines in medicinal chemistry is presented. Open-chain, flexible alicyclic amine derivatives of this motif are enumerated in key therapeutic targets, listing medicinal chemistry hits and appealing screening compounds. Latest reports in discovering new bioactive 2-phenethylamines by research groups are covered too.

引用

页数：29

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