2-Phenethylamines in Medicinal Chemistry: A Review

被引：22
|
作者：
Nieto, Carlos T. [1 ]
Manchado, Alejandro [1 ]
Belda, Leland [1 ]
Diez, David [1 ]
Garrido, Narciso M. [1 ]
机构：
[1] Univ Salamanca, Fac Chem Sci, Dept Organ Chem, Pl Caidos s n, Salamanca 37008, Spain
来源：
MOLECULES | 2023年 / 28卷 / 02期
关键词：
2-phenethylamine; medicinal chemistry; ligands; adrenoceptors; carbonyl anhydrase; dopamine receptor; DAT; 5-HT; MAO; PPAR; sigma receptors; TAAR1; ALPHA-SUBSTITUTED PHENETHYLAMINES; PROLIFERATOR-ACTIVATED-RECEPTOR; OBSTRUCTIVE PULMONARY-DISEASE; DIPEPTIDYL-PEPTIDASE-IV; ACTING BETA(2)-ADRENOCEPTOR AGONIST; REVERSE-TRANSCRIPTASE INHIBITORS; ATYPICAL BETA-ADRENOCEPTORS; IN-VITRO; CARBONIC-ANHYDRASE; PHARMACOLOGICAL CHARACTERIZATION;
D O I：
10.3390/molecules28020855
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A concise review covering updated presence and role of 2-phenethylamines in medicinal chemistry is presented. Open-chain, flexible alicyclic amine derivatives of this motif are enumerated in key therapeutic targets, listing medicinal chemistry hits and appealing screening compounds. Latest reports in discovering new bioactive 2-phenethylamines by research groups are covered too.
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页数：29
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