Synthesis of 2-(Pyridin-2-yl)phenols and 2-(Pyridin-2-yl)anilines

被引：2

作者：

Miki, Keigo ^{[1
]}

Maeda, Katsumi ^{[1
]}

Matsubara, Ryosuke ^{[1
]}

Hayashi, Masahiko ^{[1
]}

机构：

[1] Kobe Univ, Grad Sch Sci, Dept Chem, Kobe 6578501, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 08期

关键词：

HYDROXYLATION; DERIVATIVES; ACTIVATION; INHIBITORS; ARENES;

D O I：

10.1021/acs.joc.4c00423

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we report a new synthetic strategy for 2-(pyridin-2-yl)phenols and 2-(pyridin-2-yl)anilines catalyzed by a Pd/C-ethylene system. The starting materials, 2-(pyridin-2-yl)cyclohexan-1-ones, can be easily prepared by the reaction of substituted pyridine N-oxide and cyclohexanones. The most useful feature of this method is that both 2-(pyridin-2-yl)phenols and 2-(pyridin-2-yl)anilines are easily synthesized independently using the same compound as a starting material, simply by adding or not adding a nitrogen source.

引用

页码：5797 / 5810

页数：14

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