Synthesis of 2-(Pyridin-2-yl)phenols and 2-(Pyridin-2-yl)anilines

被引：2
|
作者：
Miki, Keigo [1 ]
Maeda, Katsumi [1 ]
Matsubara, Ryosuke [1 ]
Hayashi, Masahiko [1 ]
机构：
[1] Kobe Univ, Grad Sch Sci, Dept Chem, Kobe 6578501, Japan
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 08期
关键词：
HYDROXYLATION; DERIVATIVES; ACTIVATION; INHIBITORS; ARENES;
D O I：
10.1021/acs.joc.4c00423
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein, we report a new synthetic strategy for 2-(pyridin-2-yl)phenols and 2-(pyridin-2-yl)anilines catalyzed by a Pd/C-ethylene system. The starting materials, 2-(pyridin-2-yl)cyclohexan-1-ones, can be easily prepared by the reaction of substituted pyridine N-oxide and cyclohexanones. The most useful feature of this method is that both 2-(pyridin-2-yl)phenols and 2-(pyridin-2-yl)anilines are easily synthesized independently using the same compound as a starting material, simply by adding or not adding a nitrogen source.
引用
收藏
页码：5797 / 5810
页数：14
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