Impact of maternal fructose intake on liver stem/progenitor cells in offspring: Insights into developmental origins of health and disease

被引：5

作者：

Ando, Yoshitaka ^{[1
]}

Munetsuna, Eiji ^{[2
]}

Yamada, Hiroya ^{[3
]}

Ikeya, Miyuki ^{[1
]}

Teshigawara, Atsushi ^{[4
]}

Kageyama, Itsuki ^{[4
]}

Nouchi, Yuki ^{[4
]}

Wakasugi, Takuya ^{[3
]}

Yamazaki, Mirai ^{[5
]}

Mizuno, Genki ^{[6
]}

Tsuboi, Yoshiki ^{[4
]}

Ishikawa, Hiroaki ^{[1
]}

Ohgami, Nobutaka ^{[3
]}

Suzuki, Koji ^{[4
]}

Ohashi, Koji ^{[1
]}

机构：

[1] Fujita Hlth Univ, Dept Informat Clin Med, Sch Med Sci, 1-98 Dengakugakubo,Kutsukake Cho, Toyoake, Aichi 4701192, Japan

[2] Azabu Univ, Sch Vet Med, Dept Anim Sci & Biotechnol, 1-17-71 Fuchinobe,Chuo Ku, Sagamihara, Kanagawa 2525201, Japan

[3] Fujita Hlth Univ, Dept Hyg, Sch Med, 1-98 Dengakugakubo,Kutsukake Cho, Toyoake, Aichi 4701192, Japan

[4] Fujita Hlth Univ, Dept Prevent Med Sci, Sch Med Sci, 1-98 Dengakugakubo,Kutsukake Cho, Toyoake, Aichi 4701192, Japan

[5] Kagawa Prefectural Univ Hlth Sci, Dept Med Technol, 281-1 Hara,Mure Cho, Takamatsu, Kagawa 7610123, Japan

[6] Tokyo Univ Technol, Dept Med Technol, Sch Hlth Sci, 5-23-22 Nishi Kamata, Ota, Tokyo 1448535, Japan

来源：

LIFE SCIENCES | 2024年 / 336卷

关键词：

DOHaD; Maternal diet; High fructose intake; Small hepatocytes; Stem/progenitor cells; Offspring; HEPATIC PROGENITOR CELLS; DNA METHYLATION; PROLIFERATION; CARCINOGENESIS;

D O I：

10.1016/j.lfs.2023.122315

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aims: The developmental origin of health and disease (DOHaD) theory postulates that poor nutrition during fetal life increases the risk of disease later in life. Excessive fructose intake has been associated with obesity, diabetes, and nonalcoholic fatty liver disease, and maternal fructose intake during pregnancy has been shown to affect offspring health. In this study, we investigated the effects of high maternal fructose intake on the liver stem/ progenitor cells of offspring.Main method: A fructose-based DOHaD model was established using Sprague-Dawley rats. Small hepatocytes (SHs), which play an important role in liver development and regeneration, were isolated from the offspring of dams that were fed a high-fructose corn syrup (HFCS) diet. The gene expression and DNA methylation patterns were analyzed on postnatal day (PD) 21 and 60.Key findings: Maternal HFCS intake did not affect body weight or caloric intake, but differences in gene expression and DNA methylation patterns were observed in the SHs of offspring. Functional analysis revealed an association between metabolic processes and ion transport.Significance: These results suggest that maternal fructose intake affects DNA methylation and gene expression in the liver stem/progenitor cells of offspring. Furthermore, the prolonged retention of these changes in gene expression and DNA methylation in adulthood (PD 60) suggests that maternal fructose intake may exert lifelong effects. These findings provide insights into the DOHaD for liver-related disorders and highlight the importance of maternal nutrition for the health of the next generation.

引用

页数：11

共 43 条

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