Heptamethine cyanines in bioorthogonal chemistry

被引：14

作者：

Liao, Yuanyuan ^{[1
]}

Liang, Yuting ^{[1
]}

Huang, Yurou ^{[1
]}

Zeng, Xiaoyan ^{[1
]}

He, Tian ^{[1
]}

Yin, Jun ^{[1
]}

机构：

[1] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2024年 / 35卷 / 02期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

Fluorescent probes; Heptamethine cyanines; Bioorthogonal reaction; Imaging; Cell; AGGREGATION-INDUCED EMISSION; MOLECULAR DESIGN; PROBE;

D O I：

10.1016/j.cclet.2023.109092

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Due to their excellent fluorescence properties and biological function, cyanine dyes have been widely applied in biological imaging. Heptamethine cyanine (Cy7) dyes, as a type of classic near-infrared (NIR) fluorescent dyes, are considered as one of the effective fluorescent tools in the living organisms due to their good biocompatibility and very low background interference. Bioorthogonal reactions performed in living cells and tissues have developed by leaps and bounds in recent years. The NIR fluorescent labeling technique involving cyanine has attracted widespread attention. This review summarizes their recent application in the field of bioorthogonal imaging, mainly concluding Cy7-type dyes, labeling strategy, bioimaging application, etc . We expect this work can provide some helps for the studies of NIR bioorthogonal reaction in vivo .(c) 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

引用

页数：7

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