Thermoresponsive mucoadhesive hydrogel based on Pluronic F127/ thiolated glycol chitosan for intravesical administration of celecoxib/ gemcitabine

被引:6
|
作者
Ricci, Fabrizio [1 ]
Racaniello, Giuseppe Francesco [2 ]
Denora, Nunzio [2 ]
Gentile, Luigi [3 ]
Lopalco, Antonio [2 ]
Cutrignelli, Annalisa [2 ]
Franco, Massimo [2 ]
Iacobazzi, Rosa Maria [2 ]
Laquintana, Valentino [2 ]
Lopedota, Angela [2 ]
机构
[1] Univ Innsbruck, Inst Pharm, Ctr Chem & Biomed, Dept Pharmaceut Technol, A-6020 Innsbruck, Austria
[2] Univ Bari Aldo Moro, Dept Pharm Pharmaceut Sci, I-70125 Bari, Italy
[3] Univ Bari Aldo Moro, Dept Chem, I-70125 Bari, Italy
关键词
Bladder cancer; Cyclodextrin; Gemcitabine; Celecoxib; Thermoresponsive hydrogel; Thiomers; Hydrogel rheology; HYDROXYPROPYL-BETA-CYCLODEXTRIN; DRUG-DELIVERY; GELS; SURFACTANTS; DISEASE; SYSTEM; CANCER;
D O I
10.1016/j.jddst.2023.104687
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
In recent years, mucoadhesivein situ gelling formulations for intravesical application have been studied to improve the therapeutic outcomes of bladder cancer patients. Here, we carefully tuned a Pluronic F127-based thermoresponsive gel using two mucoadhesive thiolated derivatives of glycol chitosan, S-preactivated N-acetylcysteine (NAC)- and glutathione (GSH)-glycol chitosan (GC). The gel was loaded with a combination of Gemcitabine (GEM) and Celecoxib (CEX), and the aqueous solubility of the latter was increased for a synergic influence between Pluronic and the inclusion complex of 2-Hydroxypropyl-& beta;-cyclodextrin/CEX. The effect of the inclusion complex of two mucoadhesive polymers on rheological features of Pluronic based gels was highlighted to select the best performance. Finally, ex-vivo retention studies, mucosal penetration and in-vitro drug release of the selected systems were monitored for 24 h, providing enhanced retention properties (50% after 6 h) and continued drug release.
引用
收藏
页数:11
相关论文
共 35 条
  • [1] Pluronic F127/chitosan blend microspheres for mucoadhesive drug delivery
    Gu, W. Z.
    Hu, X. F.
    1ST INTERNATIONAL CONFERENCE ON NEW MATERIAL AND CHEMICAL INDUSTRY (NMCI2016), 2017, 167
  • [2] Mucoadhesive Thiolated Hyaluronic Acid/Pluronic F127 Nanogel Formation via Thiol-Maleimide Click Reaction for Intravesical Drug Delivery
    Li, Fayang
    Chen, Xianhuang
    He, Yuanqiao
    Peng, Zhiping
    ACS APPLIED BIO MATERIALS, 2024, 7 (03) : 1976 - 1989
  • [3] Chitosan/Pluronic F127 Thermosensitive Hydrogel as an Injectable Dexamethasone Delivery Carrier
    Garcia-Couce, Jomarien
    Tomas, Miriela
    Fuentes, Gaston
    Que, Ivo
    Almirall, Amisel
    Cruz, Luis J.
    GELS, 2022, 8 (01)
  • [4] In situ forming pluronic® F127/chitosan hydrogel limits metronidazole transmucosal absorption
    Malli, Sophia
    Bories, Christian
    Pradines, Benedicte
    Loiseau, Philippe M.
    Ponchel, Gilles
    Bouchemal, Kawthar
    EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2017, 112 : 143 - 147
  • [5] Thermoresponsive and Injectable Pluronic F127 Hydrogel for Loading Adipose-Derived Mesenchymal Stem Cells
    Sharun, Khan
    Banu, Shajahan Amitha
    Mamachan, Merlin
    Emmanuel, Rony S.
    Kumar, Rohit
    Vinodhkumar, Obli Rajendran
    Dhama, Kuldeep
    Pawde, Abhijit Motiram
    Maiti, Swapan Kumar
    Pal, Amar
    DISCOVERY MEDICINE, 2024, 36 (181) : 294 - 307
  • [6] Pluronic(R) F127 Thermoresponsive Viscum album Hydrogel: Physicochemical Features and Cellular In Vitro Evaluation
    Rocha, Mariana S.
    Batista, Joao V. C.
    Melo, Michelle N. O.
    de Campos, Vania E. B.
    Toledo, Anna Lecticia M. M.
    Oliveira, Adriana P.
    Picciani, Paulo H. S.
    Baumgartner, Stephan
    Holandino, Carla
    PHARMACEUTICS, 2022, 14 (12)
  • [7] Quaternized chitosan/Pluronic F127 thermosensitive hydrogel with high antibacterial properties for wound dressing
    Kaiting Cheng
    Yiming Fang
    Liang Bai
    Feng Gui
    Junchi Ma
    Huimin Gao
    Yadong Zhao
    Xingtao Xu
    Progress in Natural Science:Materials International, 2023, 33 (05) : 581 - 592
  • [8] Quaternized chitosan / Pluronic F127 thermosensitive hydrogel with high antibacterial properties for wound dressing
    Cheng, Kaiting
    Fang, Yiming
    Bai, Liang
    Gui, Feng
    Ma, Junchi
    Gao, Huimin
    Zhao, Yadong
    Xu, Xingtao
    PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL, 2023, 33 (05) : 581 - 592
  • [9] Stressed by hydrogel? Physiological response of yeast cells embedded in thermoresponsive Pluronic F127: a prerequisite for bioreactor development
    Zunar, B.
    Mosrin-Huaman, C.
    Benedetti, H.
    Guegan, R.
    Vallee, B.
    FEBS OPEN BIO, 2021, 11 : 270 - 270
  • [10] Thermoresponsive Nanoparticles Based on Poly(2-alkyl-2-Oxazolines) and Pluronic F127
    Panek, Jiri
    Filippov, Sergey K.
    Hruby, Martin
    Rabyk, Maria
    Bogomolova, Anna
    Kucka, Jan
    Stepanek, Petr
    MACROMOLECULAR RAPID COMMUNICATIONS, 2012, 33 (19) : 1683 - 1689