Spatial and Ecological Factors Modulate the Incidence of Anti-NMDAR Encephalitis-A Systematic Review

被引：5

作者：

Alentorn, Agusti ^{[1
,2
]}

Berzero, Giulia ^{[1
,2
]}

Alexopoulos, Harry ^{[3
]}

Tzartos, John ^{[4
]}

Botero, German Reyes ^{[5
]}

Martinez, Andrea Morales ^{[1
,6
,7
]}

Muniz-Castrillo, Sergio ^{[8
,9
]}

Vogrig, Alberto ^{[8
,9
]}

Joubert, Bastien ^{[8
,9
]}

Jimenez, Francisco Garcia A. ^{[10
,11
]}

Cabrera, Dagoberto ^{[12
]}

Tobon, Jose Vladimir ^{[13
]}

Delgado, Carolina ^{[6
,7
]}

Sandoval, Patricio ^{[14
]}

Troncoso, Monica ^{[15
]}

Galleguillos, Lorna ^{[16
]}

Giry, Marine ^{[2
]}

Benazra, Marion ^{[2
]}

Verdin, Isaias Hernandez ^{[2
]}

Dade, Maelle ^{[1
,2
]}

Picard, Geraldine ^{[8
,9
]}

Rogemond, Veronique ^{[8
,9
]}

Weiss, Nicolas ^{[2
,17
]}

Dalakas, Marinos C. ^{[3
]}

Boelle, Pierre-Yves ^{[18
]}

Delattre, Jean-Yves ^{[1
,2
]}

Honnorat, Jerome ^{[8
,9
]}

Psimaras, Dimitri ^{[1
,2
,19
]}

机构：

[1] Hop Univ La Pitie Salpetriere, Assistance Publ Hop Paris APHP, Dept Neurol 2 Mazarin, F-75013 Paris, France

[2] Univ Paris 06, Sorbonnes Univ, Inst Cerveau & Moelle Epiniere, Inserm U 1127,CNRS UMR 7225,ICM, F-75005 Paris, France

[3] Natl & Kapodistrian Univ Athens, Fac Med, Dept Pathophysiol, Neuroimmunol Unit, Athens 11527, Greece

[4] Natl & Kapodistrian Univ Athens, Eginit Hosp, Med Sch, Dept Neurol 1, 72-74 Vas Sofias Ave, Athens 11528, Greece

[5] Hosp Pablo Tobon Uribe, Dept Oncol, Neurooncol Sect, Medellin 050010, Colombia

[6] Hosp Clin Univ Chile, Dept Neurol, Santiago 8380456, Chile

[7] Hosp Clin Univ Chile, Dept Neurosurg, Santiago 8380456, Chile

[8] Hosp Civils Lyon, Hop Neurol, French Reference Ctr Paraneoplast Neurol Syndrome, F-69677 Bron, France

[9] Univ Lyon, Univ Claude Bernard Lyon 1, Inst NeuroMyoGene INSERM U1217, CNRS UMR 5310, F-69372 Lyon, France

[10] Univ Antioquia, Fac Med, Dept Neurol, Carrera 51d 62-29, Medellin 050010, Colombia

[11] Hosp Univ San Vicente Fdn, Dept Neurol, Calle 64 51d-154, Medellin 050010, Colombia

[12] Hosp Univ San Vicente Fdn, Dept Neuropediatry, Calle 64 51d-154, Medellin 050010, Colombia

[13] Univ Antioquia, Inst Neurol Colombia, Medellin 050010, Colombia

[14] Pontificia Univ Catolica Chile, Fac Med, Dept Neurol, Santiago 7820436, Chile

[15] Univ Chile, Hosp Clin San Borja Arriaran, Fac Med, Campus Ctr,Dept Pediat Neurol, Santiago 7800003, Chile

[16] Clin Davila, Dept Neuroimmunol, Santiago 8431657, Chile

[17] Hop Univ La Pitie Salpetriere, Assistance Publ Hop Paris APHP, Dept Neurol, Neuro ICU, F-75013 Paris, France

[18] Sorbonne Univ, Inst Pierre Louis Epidemiol & Sante Publ, INSERM, F-75012 Paris, France

[19] Grp Hosp Pitie Salpetriere, Ctr Competence Syndromes Neurol Paraneoplas & Enc, F-75013 Paris, France

来源：

BIOMEDICINES | 2023年 / 11卷 / 06期

关键词：

anti-NMDAR encephalitis; geoepidemiology; seasonality; ASPARTATE RECEPTOR ENCEPHALITIS; CLINICAL-FEATURES; AUTOIMMUNE ENCEPHALITIS; MULTIPLE-SCLEROSIS; CASE SERIES; CHILDREN; OUTCOMES; ANTIBODIES; DIAGNOSIS; EXPERIENCE;

D O I：

10.3390/biomedicines11061525

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Anti-NMDAR encephalitis has been associated with multiple antigenic triggers (i.e., ovarian teratomas, prodromal viral infections) but whether geographic, climatic, and environmental factors might influence disease risk has not been explored yet. We performed a systematic review and a meta-analysis of all published papers reporting the incidence of anti-NMDAR encephalitis in a definite country or region. We performed several multivariate spatial autocorrelation analyses to analyze the spatial variations in the incidence of anti-NMDA encephalitis depending on its geographical localization and temperature. Finally, we performed seasonal analyses in two original datasets from France and Greece and assessed the impact of temperature using an exposure-lag-response model in the French dataset. The reported incidence of anti-NMDAR encephalitis varied considerably among studies and countries, being higher in Oceania and South America (0.2 and 0.16 per 100,000 persons-year, respectively) compared to Europe and North America (0.06 per 100,000 persons-year) (p < 0.01). Different regression models confirmed a strong negative correlation with latitude (Pearson's R = -0.88, p < 0.00001), with higher incidence in southern hemisphere countries far from the equator. Seasonal analyses showed a peak of cases during warm months. Exposure-lag-response models confirmed a positive correlation between extreme hot temperatures and the incidence of anti-NMDAR encephalitis in France (p = 0.03). Temperature analyses showed a significant association with higher mean temperatures and positive correlation with higher ultraviolet exposure worldwide. This study provides the first evidence that geographic and climatic factors including latitude, mean annual temperature, and ultraviolet exposure, might modify disease risk.

引用

页数：15

共 103 条

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