Radiotherapy and Immunotherapy in Lung Cancer

被引：14

作者：

Hsieh, Kristin ^{[1
]}

Dickstein, Daniel R. ^{[1
]}

Runnels, Juliana ^{[1
]}

Lehrer, Eric J. ^{[1
]}

Rosenzweig, Kenneth ^{[1
,2
]}

Hirsch, Fred R. ^{[2
]}

Samstein, Robert M. ^{[1
,2
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Radiat Oncol, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Tisch Canc Inst, Ctr Thorac Oncol, New York, NY 10029 USA

来源：

BIOMEDICINES | 2023年 / 11卷 / 06期

关键词：

radiotherapy; immunotherapy; lung cancer; NSCLC; SCLC; RANDOMIZED PHASE-III; OPEN-LABEL; RADIATION-THERAPY; ADJUVANT VACCINATION; RESPONDING PATIENTS; COMBINATION; CONCURRENT; DURVALUMAB; CHEMORADIOTHERAPY; INHIBITORS;

D O I：

10.3390/biomedicines11061642

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The emergence of immune checkpoint inhibitors (ICIs) as a pillar of cancer treatment has emphasized the immune system's integral role in tumor control and progression through cancer immune surveillance. ICIs are being investigated and incorporated into the treatment paradigm for lung cancers across stages and histology. To date, definitive concurrent chemoradiotherapy followed by consolidative durvalumab is the only National Comprehensive Cancer Network's recommended treatment paradigm including radiotherapy with ICI in lung cancers, although there are other recommendations for ICI with chemotherapy and/or surgery. This narrative review provides an overall view of the evolving integration and synergistic role of immunotherapy and radiotherapy and outlines the use of immunotherapy with radiotherapy for the management of small cell lung cancer and non-small cell lung cancer. It also reviews selected, practice-changing clinical trials that led to the current standard of care for lung cancers.

引用

页数：14

共 88 条

[1] Neoadjuvant durvalumab with or without stereotactic body radiotherapy in patients with early-stage non-small-cell lung cancer: a single-centre, randomised phase 2 trial [J].

Altorki, Nasser K. ;

McGraw, Timothy E. ;

Borczuk, Alain C. ;

Saxena, Ashish ;

Port, Jeffrey L. ;

Stiles, Brendon M. ;

Lee, Benjamin E. ;

Sanfilippo, Nicholas J. ;

Scheff, Ronald J. ;

Pua, Bradley B. ;

Gruden, James F. ;

Christos, Paul J. ;

Spinelli, Cathy ;

Gakuria, Joyce ;

Uppal, Manik ;

Binder, Bhavneet ;

Elemento, Olivier ;

Ballman, Karla, V ;

Formenti, Silvia C. .

LANCET ONCOLOGY, 2021, 22 (06) :824-835

[2]

[Anonymous], 2022, TEST ADD RAD THER US

[3]

[Anonymous], 2023, National comprehensive cancer network clinical practice guidelines in oncology

[4] Durvalumab after Chemoradiotherapy in Stage III Non-Small-Cell Lung Cancer [J].

Antonia, S. J. ;

Villegas, A. ;

Daniel, D. ;

Vicente, D. ;

Murakami, S. ;

Hui, R. ;

Yokoi, T. ;

Chiappori, A. ;

Lee, K. H. ;

de Wit, M. ;

Cho, B. C. ;

Bourhaba, M. ;

Quantin, X. ;

Tokito, T. ;

Mekhail, T. ;

Planchard, D. ;

Kim, Y. -C. ;

Karapetis, C. S. ;

Hiret, S. ;

Ostoros, G. ;

Kubota, K. ;

Gray, J. E. ;

Paz-Ares, L. ;

de Castro Carpeno, J. ;

Wadsworth, C. ;

Melillo, G. ;

Jiang, H. ;

Huang, Y. ;

Dennis, P. A. ;

Ozguroglu, M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (20) :1919-1929

[5] Immunotherapy and radiotherapy for metastatic cancers [J].

Bang, Andrew ;

Schoenfeld, Jonathan D. .

ANNALS OF PALLIATIVE MEDICINE, 2019, 8 (03) :312-325

[6] Multicenter Evaluation of the Tolerability of Combined Treatment With PD-1 and CTLA-4 Immune Checkpoint Inhibitors and Palliative Radiation Therapy [J].

Bang, Andrew ;

Wilhite, Tyler J. ;

Pike, Luke R. G. ;

Cagney, Daniel N. ;

Aizer, Ayal A. ;

Taylor, Allison ;

Spektor, Alexander ;

Krishnan, Monica ;

Ott, Patrick A. ;

Balboni, Tracy A. ;

Hodi, F. Stephen ;

Schoenfeld, Jonathan D. .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2017, 98 (02) :344-351

[7]

Basumallik N., 2022, StatPearls

[8] Pembrolizumab After Completion of Locally Ablative Therapy for Oligometastatic Non-Small Cell Lung Cancer: A Phase 2 Trial [J].

Bauml, Joshua M. ;

Mick, Rosemarie ;

Ciunci, Christine ;

Aggarwal, Charu ;

Davis, Christiana ;

Evans, Tracey ;

Deshpande, Charuhas ;

Miller, Linda ;

Patel, Pooja ;

Alley, Evan ;

Knepley, Christina ;

Mutale, Faith ;

Cohen, Roger B. ;

Langer, Corey J. .

JAMA ONCOLOGY, 2019, 5 (09) :1283-1290

[9] High-Dose Once-Daily Thoracic Radiotherapy in Limited-Stage Small-Cell Lung Cancer: CALGB 30610 (Alliance)/RTOG 0538 [J].

Bogart, Jeffrey ;

Wang, Xiaofei ;

Masters, Gregory ;

Gao, Junheng ;

Komaki, Ritsuko ;

Gaspar, Laurie E. ;

Heymach, John ;

Bonner, James ;

Kuzma, Charles ;

Waqar, Saiama ;

Petty, William ;

Stinchcombe, Thomas E. ;

Bradley, Jeffrey D. ;

Vokes, Everett .

JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (13) :2394-+

[10] Novel patterns of response under immunotherapy [J].

Borcoman, E. ;

Kanjanapan, Y. ;

Champiat, S. ;

Kato, S. ;

Servois, V. ;

Kurzrock, R. ;

Goel, S. ;

Bedard, P. ;

Le Tourneau, C. .

ANNALS OF ONCOLOGY, 2019, 30 (03) :385-396

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