Synthesis and characterization of bioactive isoxazole and 1,3,4-oxadiazole heterocycle containing scaffolds

被引：1

作者：

Joshi, Kaushik ^{[1
]}

Mahida, Anil ^{[2
]}

Rathod, Jayant ^{[3
]}

机构：

[1] D K V Arts & Sci Coll, Dept Chem, Jamnagar 361008, Gujarat, India

[2] Govt Sci Coll, Dept Chem, Songadh 394670, Gujarat, India

[3] Govt Sci Coll, Dept Chem, Dhanpur 389382, Gujarat, India

来源：

INDIAN JOURNAL OF CHEMISTRY | 2023年 / 62卷 / 03期

关键词：

Isoxazole; 4-oxadiazole; Biheterocycles; Anti; -fungal; -bacterial; PHARMACOLOGICAL EVALUATION; DERIVATIVES; CONVERSION;

D O I：

10.56042/ijc.v62i3.72063

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein we have disclosed the design, synthesis, and study of the biological property of isoxazole and 1,3,4-oxadiazole containing framework. Set of 2-(4-(4-nitrophenoxy)phenyl)-5-(4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)phenyl)-1,3,4-oxadiazole derivatives have been constructed. Synthesized compounds have been screened for anti-fungal and anti-bacterial activities. Among them, Compound 8a have shown excellent anti-fungal activity against C.albicans fungi. Compound 8b and 8c have exhibited significant anti-bacterial activity with MIC 50 mu g/mL against S. pyogenus and S. aureus pathogens, respectively.

引用

页码：237 / 243

页数：7

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