Fabrication of Electrospun PLA-nHAp Nanocomposite for Sustained Drug Release in Dental and Orthopedic Applications

被引:7
作者
Kanak, Nishat Anzum [1 ,2 ]
Shahruzzaman, Md. [1 ]
Islam, Md. Sazedul [1 ,3 ]
Takafuji, Makoto [4 ]
Rahman, Mohammed Mizanur [1 ]
Kabir, Sumaya F. [1 ]
机构
[1] Univ Dhaka, Dept Appl Chem & Chem Engn, Dhaka 1000, Bangladesh
[2] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA
[3] Florida State Univ, Dept Chem & Biochem, Tallahassee, FL 32306 USA
[4] Kumamoto Univ, Dept Appl Chem & Biochem, Kumamoto 8608555, Japan
关键词
electrospun; nanocomposite; drug release; cytotoxicity; hydroxyapatite; ACID PLA; SCAFFOLDS; MORPHOLOGY; COMPOSITES; HYDROLYSIS; DELIVERY;
D O I
10.3390/ma16103691
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
This study describes the fabrication of nanocomposites using electrospinning technique from poly lactic acid (PLA) and nano-hydroxyapatite (n-HAp). The prepared electrospun PLA-nHAP nanocomposite is intended to be used for drug delivery application. A hydrogen bond in between nHAp and PLA was confirmed by Fourier transform infrared (FT-IR) spectroscopy. Degradation study of the prepared electrospun PLA-nHAp nanocomposite was conducted for 30 days both in phosphate buffer solution (PBS) of pH 7.4 and deionized water. The degradation of the nanocomposite occurred faster in PBS in comparison to water. Cytotoxicity analysis was conducted on both Vero cells and BHK-21 cells and the survival percentage of both cells was found to be more than 95%, which indicates that the prepared nanocomposite is non-toxic and biocompatible. Gentamicin was loaded in the nanocomposite via an encapsulation process and the in vitro drug delivery process was investigated in phosphate buffer solution at different pHs. An initial burst release of the drug was observed from the nanocomposite after 1 to 2 weeks for all pH media. After that, a sustained drug release behavior was observed for the nanocomposite for 8 weeks with a release of 80%, 70% and 50% at pHs 5.5, 6.0 and 7.4, respectively. It can be suggested that the electrospun PLA-nHAp nanocomposite can be used as a potential antibacterial drug carrier for sustained drug release in dental and orthopedic sector.
引用
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页数:16
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