The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory-Shigella spp.

被引：1

作者：

Blacksell, Stuart D. D. ^{[1
,2
]}

Dhawan, Sandhya ^{[1
]}

Kusumoto, Marina ^{[1
]}

Le, Kim Khanh ^{[1
]}

Davis, Ben J. J. ^{[1
]}

Summermatter, Kathrin ^{[3
]}

O'Keefe, Joseph ^{[4
]}

Kozlovac, Joseph ^{[5
]}

Almuhairi, Salama Suhail ^{[6
,15
]}

Sendow, Indrawati ^{[7
]}

Scheel, Christina M. M. ^{[8
]}

Ahumibe, Anthony ^{[9
]}

Masuku, Zibusiso M. M. ^{[10
]}

Bennett, Allan M. M. ^{[11
]}

Kojima, Kazunobu ^{[12
]}

Harper, David R. R. ^{[13
]}

Hamilton, Keith ^{[14
]}

机构：

[1] Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Res Med Unit, 420-6 Rajvithi Rd, Bangkok 10400, Thailand

[2] Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Nuffield Dept Med Res Bldg, Oxford, England

[3] Univ Bern, Inst Infect Dis, Bern, Switzerland

[4] Minist Primary Ind, Wellington, New Zealand

[5] USDA ARS, Beltsville, MD USA

[6] Abu Dhabi Agr & Food Safety Author, Abu Dhabi, U Arab Emirates

[7] Natl Res & Innovat Agcy, Res Ctr Vet Sci, Jakarta, Indonesia

[8] Ctr Dis Control & Prevent, WHO Collaborating Ctr Biosafety & Biosecur, Off Associate Director Lab Sci, Ctr Global Hlth, Atlanta, GA USA

[9] Nigeria Ctr Dis Control & Prevent, Abuja, Nigeria

[10] Natl Hlth Lab Serv, Natl Inst Communicable Dis, Johannesburg, South Africa

[11] UK Hlth Secur Agcy, Porton Down, England

[12] WHO, Dept Epidem & Pandem Preparedness & Prevent, Geneva, Switzerland

[13] Royal Inst Int Affairs, London, England

[14] World Org Anim Hlth OIE, Paris, France

[15] Natl Emergency Crisis & Disaster Management Author, Abu Dhabi, U Arab Emirates

来源：

APPLIED BIOSAFETY | 2023年 / 28卷 / 02期

基金：

英国惠康基金;

关键词：

Shigella spp; pathogen characteristics; biosafety evidence; knowledge gap analysis; disinfection; inactivation; BRITISH CLINICAL LABORATORIES; INFECTIONS; MANAGEMENT; SONNEI;

D O I：

10.1089/apb.2022.0046

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Introduction: Shigella bacteria cause shigellosis, a gastrointestinal infection most often acquired from contaminated food or water. Methods: In this review, the general characteristics of Shigella bacteria are described, cases of laboratory-acquired infections (LAIs) are discussed, and evidence gaps in current biosafety practices are identified. Results: LAIs are undoubtedly under-reported. Owing to the low infectious dose, rigorous biosafety level 2 practices are required to prevent LAIs resulting from sample manipulation or contact with infected surfaces. Conclusions: It is recommended that, before laboratory work with Shigella, an evidence-based risk assessment be conducted. Particular emphasis should be placed on personal protective equipment, handwashing, and containment practices for procedures that generate aerosols or droplets.

引用

页码：96 / 101

页数：6

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