Epitranscriptomics in the development, functions, and disorders of cancer stem cells

被引：3
作者：
Hao, Linlin [1 ]
Zhang, Jian [2 ]
Liu, Zhongshan [1 ]
Lin, Xia [1 ]
Guo, Jie [1 ]
机构：
[1] Second Hosp Jilin Univ, Dept Tumor Radiotherapy, Changchun, Peoples R China
[2] Southern Univ Sci & Technol, Sch Life Sci, Dept Biol, Shenzhen, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2023年 / 13卷
关键词：
epitranscriptomics; RNA modification; cancer stem cell; stemness; RNA-modifying enzyme; WNT/BETA-CATENIN PATHWAY; MESSENGER-RNA; M(6)A MODIFICATION; SELF-RENEWAL; NUCLEAR-RNA; PROSPECTIVE IDENTIFICATION; HEPATOCELLULAR-CARCINOMA; TRANSLATIONAL CONTROL; REGULATES STEMNESS; MYELOID-LEUKEMIA;
D O I：
10.3389/fonc.2023.1145766
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Biomolecular modifications play an important role in the development of life, and previous studies have investigated the role of DNA and proteins. In the last decade, with the development of sequencing technology, the veil of epitranscriptomics has been gradually lifted. Transcriptomics focuses on RNA modifications that affect gene expression at the transcriptional level. With further research, scientists have found that changes in RNA modification proteins are closely linked to cancer tumorigenesis, progression, metastasis, and drug resistance. Cancer stem cells (CSCs) are considered powerful drivers of tumorigenesis and key factors for therapeutic resistance. In this article, we focus on describing RNA modifications associated with CSCs and summarize the associated research progress. The aim of this review is to identify new directions for cancer diagnosis and targeted therapy.
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页数：16
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