The effects of a moderate physical activity intervention on physical fitness and cognition in healthy elderly with low levels of physical activity: a randomized controlled trial

被引:26
作者
Galle, Sara A. [1 ,2 ]
Deijen, Jan Berend [1 ,3 ]
Milders, Maarten V. [1 ]
De Greef, Mathieu H. G. [4 ]
Scherder, Erik J. A. [1 ]
van Duijn, Cornelia M. [2 ,5 ,6 ]
Drent, Madeleine L. [1 ,7 ]
机构
[1] Vrije Univ Amsterdam, Dept Clin Neuro & Dev Psychol, Boechorststr 7, NL-1081 BT Amsterdam, Netherlands
[2] Erasmus MC, Dept Epidmiol, POB 2040, NL-3000 CA Rotterdam, Netherlands
[3] Hersenctr Mental Hlth Inst, Marnixstr 364, NL-1016 XW Amsterdam, Netherlands
[4] Univ Groningen, Univ Med Ctr Groningen, Human Movement Sci, POB 196, NL-9700 AD Groningen, Netherlands
[5] Univ Oxford, Nuffield Dept Populat Hlth, Old Rd Campus, Oxford OX3 7LF, England
[6] Li Ka Shing Ctr Hlth Informat & Discovery, Big Data Inst, Old Rd Campus, Oxford OX3 7LF, England
[7] Amsterdam Univ Med Ctr, Dept Internal Med, Endocrinol Sect, POB 7057, NL-1007 MB Amsterdam, Netherlands
基金
欧盟地平线“2020”;
关键词
Aging; Cognition; Physical activity; Physical fitness; Apolipoprotein E; Randomized controlled trial; OLDER-ADULTS; PUBLIC-HEALTH; APOE-EPSILON-4; GENOTYPE; DEPRESSIVE SYMPTOMS; TAI CHI; EXERCISE; RELIABILITY; PERFORMANCE; VALIDITY; DEMENTIA;
D O I
10.1186/s13195-022-01123-3
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background Increasing physical activity is one of the most promising and challenging interventions to delay or prevent cognitive decline and dementia. Methods We conducted a randomized controlled trial to assess the effects of a physical activity intervention, aimed at increasing step count, in elderly with low levels of physical activity on measures of strength, balance, aerobic capacity, and cognition. Participants were assigned to 9 months of exercise counseling or active control. Results The intention-to-treat analyses show that the intervention, compared to control, increases the level of physical activity, but has no significant effect on physical fitness and cognition. Those who increased their physical activity with 35% or more show significant improvements in aerobic capacity, gait speed, verbal memory, executive functioning, and global cognition, compared to those who did not achieve a 35% increase. Limitations The number of participants that achieved the intended improvement was lower than expected. Conclusion Responder analyses suggest an improvement of physical fitness and cognition in those who achieved an increase in physical activity of at least 35%.
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页数:23
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