Increased Free Water in the Substantia Nigra in Asymptomatic LRRK2 G2019S Mutation Carriers

被引：4
|
作者：
Zhang, Dongling [1 ,2 ,3 ]
Zhou, Liche [4 ]
Shi, Yuting [5 ]
Liu, Jun
Wei, Hongjiang [5 ]
Tong, Qiqi [6 ]
He, Hongjian [7 ]
Wu, Tao [1 ,2 ,3 ]
机构：
[1] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Ctr Movement Disorders, Beijing, Peoples R China
[2] China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China
[3] Capital Med Univ, Beijing Inst Brain Disorders, Parkinsons Dis Ctr, Beijing, Peoples R China
[4] Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Neurol & Inst Neurol, Sch Med, Shanghai, Peoples R China
[5] Shanghai Jiao Tong Univ, Inst Med Imaging Technol, Sch Biomed Engn, Shanghai, Peoples R China
[6] Zhejiang Lab, Res Ctr Healthcare Data Sci, Hangzhou, Zhejiang, Peoples R China
[7] Zhejiang Univ, Coll Biomed Engn & Instrument Sci, Ctr Brain Imaging Sci & Technol, Hangzhou, Zhejiang, Peoples R China
来源：
MOVEMENT DISORDERS | 2023年 / 38卷 / 01期
基金：
国家重点研发计划; 美国国家卫生研究院; 中国国家自然科学基金;
关键词：
leucine-rich repeat kinase 2; free water; biomarker; posterior substantia nigra; PARKINSONS-DISEASE; MULTISITE; ELIMINATION; BRAIN;
D O I：
10.1002/mds.29253
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: The alteration of substantia nigra (SN) degeneration in populations at risk of Parkinson's disease (PD) is unclear. Objective: We investigated free water (FW) values in the posterior SN (pSN) in asymptomatic LRRK2 G2019S mutation carriers. Methods: We analyzed diffusion imaging data from 28 asymptomatic LRRK2 G2019S mutation carriers and 30 healthy controls (HCs), whereas 11 asymptomatic LRRK2 G2019S carriers and 11 HCs were followed up. FW values in the pSN were measured and compared between the groups. The relationship between longitudinal changes in FW in the pSN and dopamine transporter striatal binding ratio (SBR) was analyzed. Results: FW values in the pSN were significantly elevated and kept increasing during follow-up in asymptomatic LRRK2 G2019S carriers. There was a negative correlation between FW changes in the left pSN and SBR changes in the left putamen. Conclusion: FW in the pSN has the potential to be a progression imaging marker of early dopaminergic degeneration in the population at risk of PD. (c) 2022 International Parkinson and Movement Disorder Society.
引用
收藏
页码：138 / 142
页数：5
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