Lower Risk of Multisystem Inflammatory Syndrome in Children With the Delta and Omicron Variants of Severe Acute Respiratory Syndrome Coronavirus 2

被引：56

作者：

Cohen, Jonathan M. ^{[1
,2
]}

Carter, Michael J. ^{[3
,4
]}

Cheung, C. Ronny ^{[5
,6
]}

Ladhani, Shamez ^{[7
,8
]}

机构：

[1] Evelina London Childrens Hosp, Paediat Immunol & Infect Dis, 3rd Floor Becket House,Westminster Bridge Rd, London SE1 7EH, England

[2] UCL, Great Ormond St Inst Child Hlth, London, England

[3] Kings Coll London, Sch Life Course & Populat Sci, London, England

[4] Evelina London Childrens Hosp, Paediat Intens Care Unit, London, England

[5] Evelina London Childrens Hosp, Gen Paediat Dept, London, England

[6] Kings Coll London, Fac Life Sci & Med, London, England

[7] UK Hlth Secur Agcy, Immunisat Div, London, England

[8] St Georges Univ London, Paediat Infect Dis Res Grp, London, England

来源：

CLINICAL INFECTIOUS DISEASES | 2023年 / 76卷 / 03期

关键词：

SARS-CoV-2; coronavirus; COVID-19; PIMS-TS; MIS-C;

D O I：

10.1093/cid/ciac553

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Little is known about the risk of multisystem inflammatory syndrome in children (MIS-C) with different severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. In southeast England, MIS-C rates per confirmed SARS-CoV-2 infections in children aged 0-16 years were 56% lower (rate ratio [RR], 0.34 [95% confidence interval {CI}, .23-.50]) during prevaccine Delta, 66% lower (RR, 0.44 [95% CI, .28-.69]) during postvaccine Delta, and 95% lower (RR, 0.05 [95% CI, .02-.10]) during the Omicron period.

引用

页码：E518 / E521

页数：4

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